PMID- 16223530
OWN - NLM
STAT- MEDLINE
DCOM- 20060214
LR  - 20121115
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 170
IP  - 1-2
DP  - 2005 Dec 30
TI  - Alterations in cell-mediated immune response in subacute sclerosing 
      panencephalitis.
PG  - 179-85
AB  - To investigate T cell responses in subacute sclerosing panencephalitis (SSPE), we 
      analyzed proliferation and cytokine secretion of cells from 35 patients and 42 
      healthy controls (HC) in response to central nervous system (CNS) antigens. The 
      proliferation in response to myelin basic protein (MBP), myelin 
      oligodendrocyte-glycoprotein (MOG) and alphaB-crystallin did not differ between 
      groups. There was a trend towards a decrease in IL-12 production in response to 
      MBP and in vitro IL-12 secretion of SSPE patients to measles virus vaccine (MVV) 
      was lower than controls. Proliferation, as well as IFN-gamma, IL-12 and IL-10 
      production in response to purified protein derivate (PPD) was impaired in SSPE 
      patients. The results did not demonstrate any by-stander cellular response 
      against myelin antigens, implicating that CNS is not a predominant target of an 
      autoimmune response in SSPE. The recall responses were lower in SSPE as reported 
      in measles before.
FAU - Yentur, Sibel P
AU  - Yentur SP
AD  - Department of Physiology, Istanbul Medical Faculty, Istanbul University, Turkey.
FAU - Gurses, Candan
AU  - Gurses C
FAU - Demirbilek, Veysi
AU  - Demirbilek V
FAU - Yilmaz, Gulden
AU  - Yilmaz G
FAU - Onal, Ayse Emel
AU  - Onal AE
FAU - Yapici, Zuhal
AU  - Yapici Z
FAU - Yalcinkaya, Cengiz
AU  - Yalcinkaya C
FAU - Cokar, Ozlem
AU  - Cokar O
FAU - Gokyigit, Aysen
AU  - Gokyigit A
FAU - Saruhan-Direskeneli, Guher
AU  - Saruhan-Direskeneli G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051011
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (CRYAB protein, human)
RN  - 0 (Cytokines)
RN  - 0 (Intermediate Filament Proteins)
RN  - 0 (MOG protein, human)
RN  - 0 (Myelin Basic Protein)
RN  - 0 (Myelin Proteins)
RN  - 0 (Myelin-Associated Glycoprotein)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Recombinant Proteins)
RN  - 0 (alpha-Crystallin B Chain)
RN  - EC 2.7.- (Protein Kinases)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Cell Proliferation
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/biosynthesis
MH  - Humans
MH  - *Immunity, Cellular
MH  - Infant
MH  - Intermediate Filament Proteins/immunology
MH  - Monocytes/metabolism/pathology
MH  - Myelin Basic Protein/immunology
MH  - Myelin Proteins
MH  - Myelin-Associated Glycoprotein/immunology
MH  - Myelin-Oligodendrocyte Glycoprotein
MH  - Nerve Tissue Proteins/immunology
MH  - Protein Kinases/immunology
MH  - Recombinant Proteins/immunology
MH  - Subacute Sclerosing Panencephalitis/blood/*immunology/pathology
MH  - alpha-Crystallin B Chain
EDAT- 2005/10/15 09:00
MHDA- 2006/02/16 09:00
CRDT- 2005/10/15 09:00
PHST- 2005/04/15 00:00 [received]
PHST- 2005/09/09 00:00 [accepted]
PHST- 2005/10/15 09:00 [pubmed]
PHST- 2006/02/16 09:00 [medline]
PHST- 2005/10/15 09:00 [entrez]
AID - S0165-5728(05)00382-6 [pii]
AID - 10.1016/j.jneuroim.2005.09.002 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2005 Dec 30;170(1-2):179-85. doi: 10.1016/j.jneuroim.2005.09.002. 
      Epub 2005 Oct 11.