PMID- 16224190
OWN - NLM
STAT- MEDLINE
DCOM- 20051215
LR  - 20051118
IS  - 1018-2438 (Print)
IS  - 1018-2438 (Linking)
VI  - 138
IP  - 4
DP  - 2005 Dec
TI  - Increased levels of serum-specific immunoglobulin e to staphylococcal enterotoxin 
      a and B in patients with allergic rhinitis and bronchial asthma.
PG  - 305-11
AB  - BACKGROUND: The association between staphylococcal enterotoxins and atopic 
      dermatitis (AD) is well characterized. We aim to evaluate the association between 
      sensitization to staphylococcal enterotoxin A (SEA) and/or B (SEB) and the 
      development of allergic airway disease. METHODS: Two hundred and seventy-four 
      patients were grouped into allergic rhinitis (AR) and/or bronchial asthma (BA) 
      only, AD only and AR/BA+AD. The AR/BA only group was further divided into AR 
      only, AR and airway hyperresponsiveness (AR+AHR) and BA. The allergen-specific 
      and total immunoglobulin E (IgE) antibodies were determined by the CAP system. 
      The associations of sensitization to SEA/SEB with allergic airway disease were 
      analyzed by logistic regression analysis. RESULTS: The overall rate of 
      sensitization to SEA/SEB was 25.7%, whereas the rate of the AD only group (45.5%) 
      was significantly higher than that of the AR/BA only group (24.5%, chi2=8.1). 
      After sensitization to SEA/SEB, the geometric mean total IgE levels were 
      significantly elevated in patients with AR+AHR and BA, but not in those with AR 
      only. BA patients had higher geometric mean values of SEA- and SEB-specific IgE 
      than AR only and AR+AHR patients. Logistic regression revealed that AR/BA only 
      was more associated with sensitization to SEA/SEB (odds ratio 6.57) than AD only 
      and AR/BA+AD (odds ratio 2.44 and 1.72). CONCLUSIONS: Atopic status after 
      sensitization to SEA/SEB was more closely associated with BA than with other 
      airway allergy, implying that SEA/SEB may play a role in exacerbating airway 
      allergy and increasing the risk of allergic airway disease. Our study suggests 
      that staphylococcal enterotoxins play a prominent role in the pathogenesis of 
      allergic airway disease as well as AD.
CI  - Copyright (c) 2005 S. Karger AG, Basel.
FAU - Lee, Jyh-Hong
AU  - Lee JH
AD  - Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan, 
      ROC.
FAU - Lin, Yu-Tsan
AU  - Lin YT
FAU - Yang, Yao-Hsu
AU  - Yang YH
FAU - Wang, Li-Chieh
AU  - Wang LC
FAU - Chiang, Bor-Luen
AU  - Chiang BL
LA  - eng
PT  - Journal Article
DEP - 20051013
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Enterotoxins)
RN  - 37337-57-8 (enterotoxin A, Staphylococcal)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 39424-53-8 (enterotoxin B, staphylococcal)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Antigens, Dermatophagoides/immunology
MH  - Asthma/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Dermatitis, Atopic/immunology
MH  - Enterotoxins/*immunology
MH  - Female
MH  - Humans
MH  - Immunization
MH  - Immunoglobulin E/*blood/immunology
MH  - Male
MH  - Rhinitis, Allergic, Perennial/*immunology
MH  - Sex Factors
MH  - Statistics, Nonparametric
EDAT- 2005/10/15 09:00
MHDA- 2005/12/16 09:00
CRDT- 2005/10/15 09:00
PHST- 2005/03/23 00:00 [received]
PHST- 2005/08/04 00:00 [accepted]
PHST- 2005/10/15 09:00 [pubmed]
PHST- 2005/12/16 09:00 [medline]
PHST- 2005/10/15 09:00 [entrez]
AID - 88868 [pii]
AID - 10.1159/000088868 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2005 Dec;138(4):305-11. doi: 10.1159/000088868. Epub 
      2005 Oct 13.