PMID- 16224516
OWN - NLM
STAT- MEDLINE
DCOM- 20080623
LR  - 20171116
IS  - 1671-167X (Print)
IS  - 1671-167X (Linking)
VI  - 37
IP  - 5
DP  - 2005 Oct 18
TI  - [Expression of novel apoptosis-related protein PDCD5 in granulosa cells of 
      polysystic ovary syndrome].
PG  - 476-9
AB  - OBJECTIVE: To detect the novel apoptosis-related protein PDCD5 expression in 
      granulosa cells of polysystic ovary syndrome (PCOS) and normal ovary, and explore 
      the pathogenesis of PCOS. METHODS: The granulosa cells were collected from 30 
      cases of PCOS and normal ovary in IVF-ET. Expression of PDCD5 was detected by 
      flow cytometry; immunofluorescence and immunohistochemistry. Cell apoptosis was 
      detected by Propidium Iodide (PI) staining. RESULTS: The number of hypodiploidy 
      cells associated with apoptosis in granulosa cells of PCOS was greater than that 
      of the normal control. PDCD5 protein expression in PCOS granulosa cells was 
      significantly higher than that in normal ovary (P<0.05). PDCD5-positive cells 
      were mainly observed in cytoplasm. There was no significant difference between 
      the two groups in terms of age, basal serum FSH concentration, number of ampules 
      of FSH administered. CONCLUSION: Our data suggest that PDCD5 is an important 
      apoptosis regulating factor in granulosa cells of PCOS and normal ovary, which 
      might be involved in the pathogenesis of PCOS.
FAU - Sun, Chun-ling
AU  - Sun CL
AD  - Department of Obstetrics and Gynecology, Peking University Third Hospital, 
      Beijing 100083, China.
FAU - Qiao, Jie
AU  - Qiao J
FAU - Hu, Zhen-xing
AU  - Hu ZX
FAU - Zhang, Ting
AU  - Zhang T
FAU - Chen, Ying-yu
AU  - Chen YY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Beijing Da Xue Xue Bao Yi Xue Ban
JT  - Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health 
      sciences
JID - 101125284
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (PDCD5 protein, human)
SB  - IM
MH  - Adult
MH  - Apoptosis Regulatory Proteins/*biosynthesis
MH  - Female
MH  - Fertilization in Vitro
MH  - Flow Cytometry
MH  - Fluorescent Antibody Technique
MH  - Granulosa Cells/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Neoplasm Proteins/*biosynthesis
MH  - Polycystic Ovary Syndrome/*metabolism/pathology
EDAT- 2005/10/15 09:00
MHDA- 2008/06/24 09:00
CRDT- 2005/10/15 09:00
PHST- 2005/10/15 09:00 [pubmed]
PHST- 2008/06/24 09:00 [medline]
PHST- 2005/10/15 09:00 [entrez]
PST - ppublish
SO  - Beijing Da Xue Xue Bao Yi Xue Ban. 2005 Oct 18;37(5):476-9.