PMID- 16225414
OWN - NLM
STAT- MEDLINE
DCOM- 20060123
LR  - 20071114
IS  - 0889-2229 (Print)
IS  - 0889-2229 (Linking)
VI  - 21
IP  - 10
DP  - 2005 Oct
TI  - Potential herpesvirus interaction during HIV type 1 primary infection.
PG  - 869-75
AB  - One hundred twenty-three subjects with documented HIV-1 primary infection were 
      followed for over a year; 96 received highly active antiretroviral therapy 
      (HAART) at recruitment; 27 declined treatment. Fifty uninfected subjects served 
      as baseline controls. HIV-1 viral load, CD4 and CD8 T cell numbers, and serologic 
      changes to Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6), human 
      herpesvirus 8 (HHV-8), and cytomegalovirus (CMV) were monitored. Although 
      responses to HAART varied, herpesvirus reactivation frequencies did not differ 
      relative to HIV-1 virologic responses. Forty-seven subjects had reactivations to 
      a single herpesvirus type and 12 subjects to > or =2 types; no single herpesvirus 
      dominated. Antibody seroprevalence to EBV, HHV-6, and CMV were similar but HHV-8 
      infection was twice as prevalent in HIV-1-infected vs. uninfected individuals. 
      Notably, lower HIV-1 viremia (7,313 vs. 55,548 geometric mean RNA copies/ml) at 
      baseline was significantly associated with HHV-8 seropositivity (p < 0.004).
FAU - Lennette, Evelyne T
AU  - Lennette ET
AD  - Nectandra Institute, San Ramon, Costa Rica.
FAU - Busch, Michael P
AU  - Busch MP
FAU - Hecht, Frederick M
AU  - Hecht FM
FAU - Levy, Jay A
AU  - Levy JA
LA  - eng
GR  - U-1 AI41531/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - AIDS Res Hum Retroviruses
JT  - AIDS research and human retroviruses
JID - 8709376
SB  - IM
MH  - Antiretroviral Therapy, Highly Active
MH  - HIV Infections/complications/drug therapy/*virology
MH  - HIV-1/genetics/isolation & purification
MH  - Herpesviridae/classification/isolation & purification/*physiology
MH  - Herpesviridae Infections/*complications
MH  - Humans
MH  - Viral Load
MH  - Virus Activation
EDAT- 2005/10/18 09:00
MHDA- 2006/01/24 09:00
CRDT- 2005/10/18 09:00
PHST- 2005/10/18 09:00 [pubmed]
PHST- 2006/01/24 09:00 [medline]
PHST- 2005/10/18 09:00 [entrez]
AID - 10.1089/aid.2005.21.869 [doi]
PST - ppublish
SO  - AIDS Res Hum Retroviruses. 2005 Oct;21(10):869-75. doi: 10.1089/aid.2005.21.869.