PMID- 16225753
OWN - NLM
STAT- MEDLINE
DCOM- 20070509
LR  - 20131121
IS  - 1671-4083 (Print)
IS  - 1671-4083 (Linking)
VI  - 26
IP  - 11
DP  - 2005 Nov
TI  - Chemokine RANTES is upregulated in monocytes from patients with 
      hyperhomocysteinemia.
PG  - 1317-21
AB  - AIM: To investigate the changes in plasma level of the chemokine RANTES 
      (regulated upon activation, normal T cells expressed and secreted) and the 
      responsiveness of lipopolysaccharide (LPS)-induced RANTES secretion from 
      monocytes in patients with hyperhomocysteinemia (HHcy). METHODS: The plasma 
      levels of homocysteine (Hcy), folate, and RANTES were measured in 38 control 
      patients with normal Hcy levels and 40 patients with HHcy and the mRNA synthesis 
      of RANTES in isolated human monocytes was determined by RNase protection assays. 
      RESULTS: The plasma level of RANTES was elevated in HHcy patients compared with 
      controls (median 5.3 vs 3.5 ng/mL, P<0.01). LPS-induced RANTES production from 
      monocytes of HHcy patients was also increased significantly. In addition, Hcy 
      directly increased the mRNA level of RANTES in isolated normal human monocytes in 
      a time- and dose-dependent manner. CONCLUSION: Upregulated RANTES from monocytes 
      in HHcy patients may be involved in the atherogenesis of HHcy-induced 
      atherosclerosis.
FAU - Sun, Wei
AU  - Sun W
AD  - Institute of Vascular Medicine, Peking University, Beijing 100083, China.
FAU - Wang, Guang
AU  - Wang G
FAU - Zhang, Zhen-min
AU  - Zhang ZM
FAU - Zeng, Xiao-kun
AU  - Zeng XK
FAU - Wang, Xian
AU  - Wang X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Acta Pharmacol Sin
JT  - Acta pharmacologica Sinica
JID - 100956087
RN  - 0 (Chemokine CCL5)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (RNA, Messenger)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Adult
MH  - Chemokine CCL5/*biosynthesis/blood/genetics
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Folic Acid/blood
MH  - Homocysteine/administration & dosage/blood/*pharmacology
MH  - Humans
MH  - Hyperhomocysteinemia/*metabolism/pathology
MH  - Lipopolysaccharides
MH  - Male
MH  - Middle Aged
MH  - Monocytes/*metabolism
MH  - RNA, Messenger/biosynthesis/genetics
EDAT- 2005/10/18 09:00
MHDA- 2007/05/10 09:00
CRDT- 2005/10/18 09:00
PHST- 2005/10/18 09:00 [pubmed]
PHST- 2007/05/10 09:00 [medline]
PHST- 2005/10/18 09:00 [entrez]
AID - 10.1111/j.1745-7254.2005.00178.x [doi]
PST - ppublish
SO  - Acta Pharmacol Sin. 2005 Nov;26(11):1317-21. doi: 
      10.1111/j.1745-7254.2005.00178.x.