PMID- 16226147
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20060316
LR  - 20051017
IS  - 0379-0738 (Print)
IS  - 0379-0738 (Linking)
VI  - 155
IP  - 2-3
DP  - 2005 Dec 20
TI  - Basic and neutral route specific impurities in MDMA prepared by different 
      synthesis methods. Comparison of impurity profiles.
PG  - 100-11
AB  - In this work, the neutral and basic impurities found in the precipitate of 
      MDMA(*)HCl are presented. MDMA.HCl was prepared by the most popular synthesis 
      methods used in clandestine manufacture, i.e. safrole bromination, Leuckart 
      method and reductive amination with various reducing agents: Al/Hg, NaBH(4), 
      NaBH(3)CN. 3,4-Methylenedioxyphenyl-2-propanone (MDP-2-P), the starting material 
      in Leuckart reaction and reductive amination, was prepared by two different 
      synthesis methods, i.e. by isosafrole oxidation and MDP-2-nitropropene reduction. 
      The extraction of impurities was performed under alkaline and neutral conditions. 
      Impurity profiles were obtained using GC/MS. Each synthesis method is 
      characterised by its own route specific impurities. The influence of pH on the 
      extraction of synthesis markers from 3,4-methylenedioxymethamphetamine (MDMA) 
      samples is discussed and comparison of the profiles of basic and neutral 
      impurities is presented.
FAU - Swist, M
AU  - Swist M
AD  - Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian 
      University, Ingardena 3, 30-060 Krakow, Poland. brozek@chemia.uj.edu.pl
FAU - Wilamowski, J
AU  - Wilamowski J
FAU - Parczewski, A
AU  - Parczewski A
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
EDAT- 2005/10/18 09:00
MHDA- 2005/10/18 09:01
CRDT- 2005/10/18 09:00
PHST- 2004/04/15 00:00 [received]
PHST- 2004/11/12 00:00 [revised]
PHST- 2004/11/12 00:00 [accepted]
PHST- 2005/10/18 09:00 [pubmed]
PHST- 2005/10/18 09:01 [medline]
PHST- 2005/10/18 09:00 [entrez]
AID - S0379-0738(04)00747-9 [pii]
AID - 10.1016/j.forsciint.2004.11.003 [doi]
PST - ppublish
SO  - Forensic Sci Int. 2005 Dec 20;155(2-3):100-11. doi: 
      10.1016/j.forsciint.2004.11.003.