PMID- 16228064
OWN - NLM
STAT- MEDLINE
DCOM- 20060328
LR  - 20151119
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 26
IP  - 10
DP  - 2005 Oct
TI  - P53 and heat shock protein 70 expressions in colorectal adenocarcinoma.
PG  - 1602-6
AB  - OBJECTIVE: To examine the localization and over expression of heat shock protein 
      70 (HSP70) and p53 in patients with colorectal cancer and compared it with 
      control tissue (including normal colon tissue). METHODS: This was a retrospective 
      study of 60 patients with colorectal adenocarcinoma at the Jordan University of 
      Science and Technology (JUST), Irbid, Jordan from 1997 to 2000. The Pathology 
      Department at JUST is the chief provider of surgical pathology services in the 
      north of Jordan. It receives specimens from both government and private 
      hospitals. Immunohistochemistry was the technique of choice. RESULTS: The HSP70 
      was over expressed more highly in colorectal cancers than in the control tissue. 
      Immuno-histochemistry showed that over expression of HSP70 had no statistically 
      significant difference with any of the different prognostic factors assessed, 
      mainly the grade and the stage. The p53 was over expressed in 60% of the cases. 
      Control tissue (normal colon) was negative, p53, cell-cycle-related oncogene 
      product, was strongly over expressed in the nuclei of the cancer cells of the 
      cancer tissue. We found no significant difference in terms of size, patient age, 
      lymph node state, and stage. The rate of expression was significantly less in 
      high grade tumors than in intermediate and low grade ones. CONCLUSION: The strong 
      expression however, may be valuable in estimating a prognosis for patients with 
      colo-rectal carcinoma.
FAU - Shotar, Ali M
AU  - Shotar AM
AD  - Department of Legal Medicine, Toxicology and Forensic Science, School of 
      Medicine, Jordan University of Science and Technology, Irbid, Jordan. 
      alishoter@yahoo.com
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Adenocarcinoma/*pathology/physiopathology
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*analysis
MH  - Biopsy, Needle
MH  - Case-Control Studies
MH  - Colorectal Neoplasms/*pathology/physiopathology
MH  - Female
MH  - HSP70 Heat-Shock Proteins/analysis/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Reference Values
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Tumor Suppressor Protein p53/*metabolism
EDAT- 2005/10/18 09:00
MHDA- 2006/03/29 09:00
CRDT- 2005/10/18 09:00
PHST- 2005/10/18 09:00 [pubmed]
PHST- 2006/03/29 09:00 [medline]
PHST- 2005/10/18 09:00 [entrez]
AID - 20050388' [pii]
PST - ppublish
SO  - Saudi Med J. 2005 Oct;26(10):1602-6.