PMID- 1622900
OWN - NLM
STAT- MEDLINE
DCOM- 19920807
LR  - 20190510
IS  - 0953-8178 (Print)
IS  - 0953-8178 (Linking)
VI  - 4
IP  - 2
DP  - 1992 Feb
TI  - Isolation of human minor histocompatibility peptides.
PG  - 301-4
AB  - Incompatibility of human minor histocompatibility (hmH) antigens induces 
      rejection of grafts in organ transplantation and graft versus host disease in 
      bone marrow transplantation if donor and recipient are matched for human 
      leukocyte antigen (HLA) genes. These antigens are recognized only by T cells. We 
      describe here the isolation of hmH peptides recognized by a hmH antigen specific, 
      HLA-B35 restricted CTL clone which was derived from a patient who rejected the 
      kidneys from two HLA-identical sisters. Naturally occurring hmH peptides were 
      isolated from a donor derived B cell line and an HLA-B35 transfected human B cell 
      line by acid elution. Analysis of various HLA class I transfectant cells 
      demonstrated that MHC class I molecules themselves determine the peptides which 
      are naturally processed and presented to T cells.
FAU - Sekimata, M
AU  - Sekimata M
AD  - Department of Immunology, University of Tokyo, Japan.
FAU - Griem, P
AU  - Griem P
FAU - Egawa, K
AU  - Egawa K
FAU - Rammensee, H G
AU  - Rammensee HG
FAU - Takiguchi, M
AU  - Takiguchi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int Immunol
JT  - International immunology
JID - 8916182
RN  - 0 (Minor Histocompatibility Antigens)
SB  - IM
MH  - B-Lymphocytes/immunology
MH  - Cell Transformation, Viral
MH  - Chromatography, High Pressure Liquid
MH  - Clone Cells
MH  - Graft Rejection/immunology
MH  - Humans
MH  - Kidney Transplantation/immunology
MH  - Minor Histocompatibility Antigens/*isolation & purification
MH  - Ultracentrifugation
EDAT- 1992/02/01 00:00
MHDA- 1992/02/01 00:01
CRDT- 1992/02/01 00:00
PHST- 1992/02/01 00:00 [pubmed]
PHST- 1992/02/01 00:01 [medline]
PHST- 1992/02/01 00:00 [entrez]
AID - 10.1093/intimm/4.2.301 [doi]
PST - ppublish
SO  - Int Immunol. 1992 Feb;4(2):301-4. doi: 10.1093/intimm/4.2.301.