PMID- 16229202
OWN - NLM
STAT- MEDLINE
DCOM- 20051121
LR  - 20190917
IS  - 0042-8450 (Print)
IS  - 0042-8450 (Linking)
VI  - 62
IP  - 9
DP  - 2005 Sep
TI  - Psoriatic arthritis: a retrospective study of 162 patients.
PG  - 613-20
AB  - AIM: The aim of our study was to determine the prevalence of psoriatic arthritis 
      in the patients with psoriasis and to analyze retrospectively the results of a 
      34-year multidisciplinary management of the patients with psoriatic arthritis. 
      METHODS: The study included 162 out of 183 treated patients with psoriatic 
      arthritis, aged 48 +/- 15 years. All the patients satisfied the current 
      diagnostic criteria for psoriasis and psoriatic arthritis according to the 
      American College of Rheumatology. RESULTS: Psoriatic arthritis developed in 183 
      (9.3%) out of 1976 patients with psoriasis. Time interval for establishing the 
      diagnosis was 4 years. A positive family history of the disease had 15.0% of the 
      studied patients. Its onset was most often at 42 years of age in 70.4% of the 
      cases, and 2 months to 59 years after the appearance of psoriasis. Psoriatic 
      arthritis without psoriasis appeared in 1.8% of the patients. A severe form of 
      arthritis had 64.2% of the patients, mainly the patients with scalp psoriasis 
      (chi2 = 3.2; p < 0.05). Nail changes had 35% of the patients. Distal 
      interphalangeal joints were involved in 63.6%, axial skeleton in 36.4%, 
      oligoarthritis in 45.0%, polyarthritis in 55.0%, and mutilating form in 6.8% of 
      the patients. Elevated Erythrocyte Sedimentation Rate was reveald in 61.7% of the 
      patients. Immunoglobulin M (IgM) rheumatoid factor was altered in 4.3% of the 
      patients. The human leukocyte antigen (HLA) typing in the 28 patients were: A2 
      32.0%, A3 18.0%, Al and A9 14.0%, A28 and A29 3.5%, B8 and B16 14.0%, B5 and B12 
      11.0%, B13, B15, B18, B27 and B35 7.0%. Radiologic changes were most often in 
      hand and foot joints, less frequently in the knees and quite infrequently in hips 
      and shoulders joints. Sacroiliitis was found in 46.4% of the patients. Psoriasis 
      was treated with topical corticosteroids and salicylic ointments in all the 
      patients, ultraviolet (PUVA therapy) in 5.6% and retinoids in 4.3% of them. 
      Artrithis was treated with nonsteroidal anti-inflammatory drugs, with systemic 
      corticosteroids 41.3% and with disease modified antirheumatic drugs, most 
      frequently methotrexate, 59.9% of the patients. Radionuclide synovectomy was 
      performed in 6.8%, surgery in 6.2% and physical therapy in all the patients. 
      CONCLUSION: Psoriatic arthritis developed in 9.3% of the psoriatic patients. Time 
      interval for establishing the diagnosis was long, and there were no specific 
      laboratory findings. All the synovial joints could be involved in the psoriatic 
      process. Scintigraphy should be used only in case of early suspected 
      sacroiliitis. The treatment of psoriatic arthritis was the teamwork between the 
      dermatologist, rheumatologist, physiatrist and orthopedic surgeon.
FAU - Pavlica, Ljiljana
AU  - Pavlica L
AD  - Military Medical Academy, Clinic of Rheumatology and Clinical Immunology, 
      Belgrade.
FAU - Peric-Hajzler, Zorica
AU  - Peric-Hajzler Z
FAU - Jovelic, Aleksandra
AU  - Jovelic A
FAU - Sekler, Boris
AU  - Sekler B
FAU - Damjanovic, Milorad
AU  - Damjanovic M
LA  - eng
PT  - Journal Article
PL  - Serbia
TA  - Vojnosanit Pregl
JT  - Vojnosanitetski pregled
JID - 21530700R
RN  - 0 (HLA Antigens)
SB  - IM
CIN - Vojnosanit Pregl. 2005 Dec;62(12):949; author reply 950. PMID: 16375227
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Arthritis, Psoriatic/diagnosis/immunology/pathology
MH  - Female
MH  - HLA Antigens
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psoriasis/complications/pathology
EDAT- 2005/10/19 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/10/19 09:00
PHST- 2005/10/19 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/10/19 09:00 [entrez]
AID - 10.2298/vsp0509613p [doi]
PST - ppublish
SO  - Vojnosanit Pregl. 2005 Sep;62(9):613-20. doi: 10.2298/vsp0509613p.