PMID- 16230266
OWN - NLM
STAT- MEDLINE
DCOM- 20060522
LR  - 20071115
IS  - 1071-9164 (Print)
IS  - 1071-9164 (Linking)
VI  - 11
IP  - 8
DP  - 2005 Oct
TI  - Poor relationship between exercise capacity and spirometric measurements in 
      patients with more symptomatic heart failure.
PG  - 619-23
AB  - BACKGROUND: The origin of exercise limitation in patients with chronic heart 
      failure (CHF) is multifactorial, and the relative contributions of different 
      abnormalities may vary with severity of heart failure symptoms. The aim of the 
      current study was to determine the extent to which spirometric indices predict 
      peak exercise capacity in patients with differing severity of symptoms. METHODS 
      AND RESULTS: A total of 340 patients with left ventricular systolic dysfunction 
      underwent spirometry, and a ramped, maximal exercise treadmill test with 
      metabolic gas exchange measurements. For comparative purposes, a group of 174 
      aged-matched controls with no major structural heart disease (MSHD) was also 
      included. In a stepwise linear regression model, forced expiratory volume in 1 
      second (FEV1) and forced vital capacity (FVC) were independent predictors of peak 
      oxygen uptake (pVO2) in controls (r2= 18-25%; P = .001) and New York Heart 
      Association (NYHA) I-II patients (r2= 16-18%; P = .001). No association between 
      spirometric indices (FEV1/FVC) and pVO2 (r2= 1-2%; P > .05) was found in NYHA 
      III-IV patients. CONCLUSION: In aged-matched controls with no MSHD, spirometric 
      variables (FEV1/FVC) explain 18% to 25% of the variance in pVO2, and 16% to 18% 
      of the variance in patients with NYHA class I-II symptoms. As symptoms worsen, 
      the influence of spirometric variables on peak exercise capacity diminishes, and 
      there is no such relation in the NYHA class III-IV patients.
FAU - Ingle, Lee
AU  - Ingle L
AD  - Department of Academic Cardiology, Castle Hill Hospital, Castle Road, Cottingham, 
      Hull, United Kingdom.
FAU - Shelton, Rhidian J
AU  - Shelton RJ
FAU - Cleland, John G F
AU  - Cleland JG
FAU - Clark, Andrew L
AU  - Clark AL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Aged
MH  - Exercise Test
MH  - *Exercise Tolerance
MH  - Female
MH  - Forced Expiratory Volume
MH  - Heart Failure/*physiopathology
MH  - Heart Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption
MH  - Physical Endurance
MH  - Predictive Value of Tests
MH  - Severity of Illness Index
MH  - *Spirometry
MH  - Stroke Volume
MH  - Systole
MH  - Ventricular Dysfunction, Left/physiopathology
MH  - Vital Capacity
EDAT- 2005/10/19 09:00
MHDA- 2006/05/23 09:00
CRDT- 2005/10/19 09:00
PHST- 2004/12/30 00:00 [received]
PHST- 2005/06/02 00:00 [revised]
PHST- 2005/06/06 00:00 [accepted]
PHST- 2005/10/19 09:00 [pubmed]
PHST- 2006/05/23 09:00 [medline]
PHST- 2005/10/19 09:00 [entrez]
AID - S1071-9164(05)00677-9 [pii]
AID - 10.1016/j.cardfail.2005.06.430 [doi]
PST - ppublish
SO  - J Card Fail. 2005 Oct;11(8):619-23. doi: 10.1016/j.cardfail.2005.06.430.