PMID- 16231278
OWN - NLM
STAT- MEDLINE
DCOM- 20060103
LR  - 20191210
IS  - 0007-1323 (Print)
IS  - 0007-1323 (Linking)
VI  - 92
IP  - 12
DP  - 2005 Dec
TI  - Endoscopic ultrasonography for evaluation of pancreatic tumours in multiple 
      endocrine neoplasia type 1.
PG  - 1508-12
AB  - BACKGROUND: Pancreatic tumours are common in patients with multiple endocrine 
      neoplasia type 1 (MEN1), and close surveillance is needed to detect pancreatic 
      lesions at an early stage. Conventional radiology is inefficient in verifying the 
      small tumours indicated by biochemical screening. During the past decade, 
      endoscopic ultrasonography (EUS) has evolved as a sensitive method for the 
      detection of small pancreatic lesions. METHODS: EUS was evaluated in 25 patients 
      with MEN1, two of whom had symptoms due to hormonal secretion. Twenty-two 
      patients had biochemical signs of pancreatic tumours, and in five patients 
      lesions were located by either computed tomography (two) or transabdominal 
      ultrasonography (three). RESULTS: EUS visualized pancreatic tumours in the five 
      patients in whom lesions were detected by the other methods and in a further nine 
      patients. Eight of these 14 patients had surgery, and tumours were confirmed 
      histopathologically. No lesion was detected in any of the 11 patients with no 
      tumour detected by EUS. CONCLUSION: EUS is a more sensitive technique for the 
      detection and localization of potentially malignant lesions in patients with MEN1 
      than computed tomography or transabdominal ultrasonography.
CI  - Copyright (c) 2005 British Journal of Surgery Society Ltd. Published by John 
      Wiley & Sons, Ltd.
FAU - Hellman, P
AU  - Hellman P
AD  - Department of Surgery, University Hospital, SE-751 85 Uppsala, Sweden. 
      per.hellman@surgsci.uu.se
FAU - Hennings, J
AU  - Hennings J
FAU - Akerstrom, G
AU  - Akerstrom G
FAU - Skogseid, B
AU  - Skogseid B
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - England
TA  - Br J Surg
JT  - The British journal of surgery
JID - 0372553
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Endosonography/*instrumentation/methods
MH  - Equipment Design
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*diagnostic imaging
MH  - Pancreatic Neoplasms/*diagnostic imaging/surgery
MH  - Preoperative Care/methods
EDAT- 2005/10/19 09:00
MHDA- 2006/01/04 09:00
CRDT- 2005/10/19 09:00
PHST- 2005/10/19 09:00 [pubmed]
PHST- 2006/01/04 09:00 [medline]
PHST- 2005/10/19 09:00 [entrez]
AID - 10.1002/bjs.5149 [doi]
PST - ppublish
SO  - Br J Surg. 2005 Dec;92(12):1508-12. doi: 10.1002/bjs.5149.