PMID- 16233193
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20051103
LR  - 20191026
IS  - 1389-1723 (Print)
IS  - 1347-4421 (Linking)
VI  - 93
IP  - 2
DP  - 2002
TI  - Post-transcriptional regulation of immunomodulatory cytokines production in human 
      skin fibroblasts by intense mechanical stresses.
PG  - 234-9
AB  - We found that extremely high hydrostatic pressure stresses induced a variety of 
      cytokines production in normal human dermal fibroblasts. Normal human dermal 
      fibroblasts were found to survive and were active in producing interleukin (IL) 
      -6, -8, and monocyte chemoattractant protein-1 (MCP-1) under extremely high 
      hydrostatic pressure, up to 70 MPa (=690.8 atm=713.8 kgf/cm2). 70 MPa pressure 
      application extremely enhanced IL-6 and IL-8 secretions (about 130 folds) without 
      transcriptional enhancement. Although induction of IL-1alpha, IL-1beta, and IL-12 
      mRNAs was appeared under high hydrostatic pressure condition, no translation of 
      IL-1alpha, IL-1beta, and IL-12 proteins was found. Extracellular accumulation of 
      constitutively produced MCP-1 was down regulated in the pressure-applied 
      fibroblasts in the absence of transcriptional repression. These results indicated 
      that hydrostatic pressure stresses triggered post-transcriptional regulation 
      mechanisms that modulated the cytokines production.
FAU - Koyama, Sumihiro
AU  - Koyama S
AD  - Frontier Research Program for Deep-sea Extremophiles, Japan Marine Science and 
      Technology Center, 2-15 Natsushima-cho, Yokosuka 237-0061, Japan. 
      skoyama@jamstec.go.jp
FAU - Fujii, Shinsuke
AU  - Fujii S
FAU - Aizawa, Masuo
AU  - Aizawa M
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Biosci Bioeng
JT  - Journal of bioscience and bioengineering
JID - 100888800
EDAT- 2005/10/20 09:00
MHDA- 2005/10/20 09:01
CRDT- 2005/10/20 09:00
PHST- 2001/10/11 00:00 [received]
PHST- 2001/11/29 00:00 [accepted]
PHST- 2001/10/11 00:00 [received]
PHST- 2001/11/29 00:00 [accepted]
PHST- 2005/10/20 09:00 [pubmed]
PHST- 2005/10/20 09:01 [medline]
PHST- 2005/10/20 09:00 [entrez]
AID - S1389-1723(02)80020-2 [pii]
AID - 10.1263/jbb.93.234 [doi]
PST - ppublish
SO  - J Biosci Bioeng. 2002;93(2):234-9. doi: 10.1263/jbb.93.234.