PMID- 16233796
OWN - NLM
STAT- MEDLINE
DCOM- 20051115
LR  - 20220331
IS  - 1389-1723 (Print)
IS  - 1347-4421 (Linking)
VI  - 99
IP  - 4
DP  - 2005 Apr
TI  - Bioartificial liver systems: current status and future perspective.
PG  - 311-9
AB  - Because the liver is a multifunctional and a vital organ for survival, the 
      management of acute liver failure requires the support of a huge number of 
      metabolic functions performed by the organ. Many early detoxification-based 
      artificial liver techniques failed to treat the patients owing to the inadequate 
      support of the many essential hepatic functions. For this reason, a bioartificial 
      liver (BAL) comprising of viable hepatocytes on a mechanical support is believed 
      to more likely provide these essential functions than a purely mechanical device. 
      From 1990, nine clinical studies of various BAL systems have been reported, most 
      of which utilize a hollow fiber technology, and a much larger number of various 
      BAL systems have been suggested to show an enhanced performance. Safety issues 
      such as immunological reactions, zoonosis and tumorgenicity have been 
      successfully addressed for regulatory approval, but a recent report from a 
      large-scale, randomized, and controlled phase III trial of a leading BAL system 
      (HepatAssist) failed to meet our expectation of efficacy in terms of the overall 
      survival rate. In this paper, we review the current BAL systems actively studied 
      and discuss critical issues such as the hepatocyte bioreactor configuration and 
      the hepatocyte source. On the basis of the insights gained from previously 
      developed BAL systems and the rapid progress in stem cell technology, the 
      short-term and long-term future perspectives of BAL systems are suggested.
FAU - Park, Jung-Keug
AU  - Park JK
AD  - Department of Chemical and Biochemical Engineering, Dongguk University, 3-26 
      Pil-dong, Choong-gu, Seoul 100-715, Korea. jkpark@dongguk.edu
FAU - Lee, Doo-Hoon
AU  - Lee DH
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - J Biosci Bioeng
JT  - Journal of bioscience and bioengineering
JID - 100888800
SB  - IM
MH  - Animals
MH  - Bioprosthesis/*trends
MH  - Cell Culture Techniques/*methods/*trends
MH  - Cells, Cultured
MH  - Clinical Trials as Topic
MH  - Forecasting
MH  - Hepatocytes/cytology/physiology/*transplantation
MH  - Humans
MH  - Liver Transplantation/methods/trends
MH  - Liver, Artificial/*trends
MH  - Tissue Engineering/*methods/*trends
RF  - 86
EDAT- 2005/10/20 09:00
MHDA- 2005/11/16 09:00
CRDT- 2005/10/20 09:00
PHST- 2005/01/26 00:00 [received]
PHST- 2005/02/12 00:00 [accepted]
PHST- 2005/10/20 09:00 [pubmed]
PHST- 2005/11/16 09:00 [medline]
PHST- 2005/10/20 09:00 [entrez]
AID - S1389-1723(05)70373-X [pii]
AID - 10.1263/jbb.99.311 [doi]
PST - ppublish
SO  - J Biosci Bioeng. 2005 Apr;99(4):311-9. doi: 10.1263/jbb.99.311.