PMID- 16234008
OWN - NLM
STAT- MEDLINE
DCOM- 20060110
LR  - 20191109
IS  - 1542-3565 (Print)
IS  - 1542-3565 (Linking)
VI  - 3
IP  - 8
DP  - 2005 Aug
TI  - Variability in flexible sigmoidoscopy performance among examiners in a screening 
      trial.
PG  - 792-7
AB  - BACKGROUND & AIMS: The efficacy of flexible sigmoidoscopy (FSG) in reducing 
      colorectal cancer mortality is being evaluated in randomized trials. In 2 
      European trials, wide variability across examiners in FSG performance was noted. 
      We report on the performance of examiners in the US randomized trial: the 
      Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. METHODS: Screening 
      was performed at 10 geographically dispersed clinical centers. Patients with 
      screens positive for a lesion or mass were referred to their private health care 
      providers for endoscopic follow-up evaluation; lesions were not removed and a 
      biopsy examination was not performed at screening. FSG performance among 64 
      examiners at these centers, each performing 100 or more baseline FSG 
      examinations, with an aggregate of almost 50,000 examinations, was analyzed. 
      RESULTS: Screen-positivity results among examiners ranged from 9%-58%, with a 
      coefficient of variation (CV) of 36%. CVs were 29% for distal polyp detection and 
      21% for distal adenoma detection. Inadequate rates ranged from 1%-27% (CV, 52%). 
      Examiners with higher screen-positivity rates had higher false-positive rates, 
      defined as a positive screen with no distal lesion found on endoscopic follow-up 
      evaluation. CONCLUSIONS: Considerable variability exists in the rates of positive 
      screens and in polyp and adenoma detection rates among FSG examiners performing 
      the procedures using a common protocol.
FAU - Pinsky, Paul F
AU  - Pinsky PF
AD  - Division of Cancer Prevention, National Cancer Institute, National Institutes of 
      Health, Bethesda, Maryland, USA. pp4f@nih.gov
FAU - Schoen, Robert E
AU  - Schoen RE
FAU - Weissfeld, Joel L
AU  - Weissfeld JL
FAU - Kramer, Barnett
AU  - Kramer B
FAU - Hayes, Richard B
AU  - Hayes RB
FAU - Yokochi, Lance
AU  - Yokochi L
CN  - PLCO Project Team
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Clin Gastroenterol Hepatol
JT  - Clinical gastroenterology and hepatology : the official clinical practice journal 
      of the American Gastroenterological Association
JID - 101160775
SB  - IM
MH  - Adenoma/diagnosis
MH  - Aged
MH  - Colonic Polyps/diagnosis
MH  - Colorectal Neoplasms/diagnosis/*prevention & control
MH  - False Positive Reactions
MH  - Female
MH  - Gastroenterology
MH  - Humans
MH  - Male
MH  - Mass Screening/*statistics & numerical data
MH  - Middle Aged
MH  - Nurse Practitioners
MH  - Randomized Controlled Trials as Topic
MH  - Sex Factors
MH  - Sigmoidoscopy/*statistics & numerical data
MH  - Smoking/adverse effects
MH  - United States
EDAT- 2005/10/20 09:00
MHDA- 2006/01/13 09:00
CRDT- 2005/10/20 09:00
PHST- 2005/10/20 09:00 [pubmed]
PHST- 2006/01/13 09:00 [medline]
PHST- 2005/10/20 09:00 [entrez]
AID - S1542-3565(05)00286-7 [pii]
AID - 10.1016/s1542-3565(05)00286-7 [doi]
PST - ppublish
SO  - Clin Gastroenterol Hepatol. 2005 Aug;3(8):792-7. doi: 
      10.1016/s1542-3565(05)00286-7.