PMID- 16235996
OWN - NLM
STAT- MEDLINE
DCOM- 20051207
LR  - 20170308
IS  - 1513-7368 (Print)
IS  - 1513-7368 (Linking)
VI  - 6
IP  - 3
DP  - 2005 Jul-Sep
TI  - Suppressive effects of fruit-juice concentrate of Prunus mume Sieb. et Zucc. 
      (Japanese apricot, Ume) on Helicobacter pylori-induced glandular stomach lesions 
      in Mongolian gerbils.
PG  - 337-41
AB  - Helicobacter pylori (Hp) infection is an important factor in human gastric 
      disorders, including chronic active gastritis, peptic ulcers, intestinal 
      metaplasia and cancer. Since epidemiologic studies overwhelmingly agree on a 
      protective influence of fruits and vegetables in reducing the risk of gastric 
      neoplasia and processed foods made from Prunus mume Sieb. et Zucc. (Japanese 
      apricot or "Ume" in Japanese) are traditionally known for their miscellaneous 
      medical effects, in the present study we investigated the efficacy of a 
      fruit-juice concentrate of Japanese apricot (CJA) in the glandular stomach of 
      Hp-infected Mongolian gerbils. Hp-inoculated gerbils were given CJA in their 
      drinking water at concentrations of 1 and 3% for 10 weeks. The microscopic scores 
      for gastritis and mucosal hyperplasia in the CJA groups were significantly lower 
      than in the Hp-inoculated control group, with dose-dependence. Real-time PCR was 
      performed to quantitate Hp by demonstrating urease A gene amount using gerbils 
      glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene as an internal control. 
      Average relative urease A gene dosage in the glandular stomach in the 1 and 3% 
      CJA and Hp-inoculated control groups was 26.6 +/- 11.6% (average +/- SE), 30.3 
      +/- 10.5%, 100 +/- 40.9%, respectively, the fruit-juice concentrate causing 
      significant lowering (P<0.01 and P<0.05, respectively, with 1 and 3%). These 
      findings suggest that suppressive effects on gastric cancer development might 
      also be expected as a result of decreased numbers of Hp and improvement of 
      Hp-induced chronic active gastritis on administration of CJA.
FAU - Otsuka, Takafumi
AU  - Otsuka T
AD  - Division of Oncological Pathology, Aichi Cancer Center Research Institute, 1-1 
      Kanokoden, Chukusa, Nagoya 464-8681, Japan.
FAU - Tsukamoto, Tetsuya
AU  - Tsukamoto T
FAU - Tanaka, Harunari
AU  - Tanaka H
FAU - Inada, Kenichi
AU  - Inada K
FAU - Utsunomiya, Hirotoshi
AU  - Utsunomiya H
FAU - Mizoshita, Tsutomu
AU  - Mizoshita T
FAU - Kumagai, Toshiko
AU  - Kumagai T
FAU - Katsuyama, Tsutomu
AU  - Katsuyama T
FAU - Miki, Kazumasa
AU  - Miki K
FAU - Tatematsu, Masae
AU  - Tatematsu M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (Plant Extracts)
RN  - EC 1.2.1.9 (Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+))
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - *Beverages
MH  - Gastritis/*microbiology/*prevention & control
MH  - Gerbillinae
MH  - Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+)/genetics/metabolism
MH  - Helicobacter Infections/*complications
MH  - Helicobacter pylori/pathogenicity
MH  - Inflammation
MH  - Male
MH  - Plant Extracts/*pharmacology
MH  - Polymerase Chain Reaction
MH  - Prunus/*chemistry
MH  - Stomach Neoplasms/*microbiology/*prevention & control
EDAT- 2005/10/21 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/10/21 09:00
PHST- 2005/10/21 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/10/21 09:00 [entrez]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2005 Jul-Sep;6(3):337-41.