PMID- 16236264
OWN - NLM
STAT- MEDLINE
DCOM- 20051230
LR  - 20181201
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 337
IP  - 4
DP  - 2005 Dec 2
TI  - Annexin A3 is a potential angiogenic mediator.
PG  - 1283-7
AB  - Angiogenesis is a complex process that is regulated by a variety of angiogenic 
      activators and inhibitors. Disruption of the balanced angiogenesis leads to the 
      progress of diseases such as tumor growth, rheumatoid arthritis, and various 
      blood vessel-related disorders. Even though a number of proteins involved in 
      angiogenesis have been identified so far, more protein factors remain to be 
      identified due to complexity of the process. Here we report that annexin A3 
      (ANXA3) induces migration and tube formation of human umbilical vein endothelial 
      cells. High level of vascular endothelial growth factor (VEGF), a prominent 
      angiogenic factor, is also detected in conditioned medium obtained from cells 
      transfected with ANXA3 expression plasmid. Reporter assays show that ANXA3 
      enhances hypoxia-inducible factor-1 (HIF-1) transactivation activity. Taken 
      together, our results suggest that ANXA3 is a novel angiogenic factor that 
      induces VEGF production through the HIF-1 pathway.
FAU - Park, Jae Eun
AU  - Park JE
AD  - Systemic Proteomics Research Center, Korea Research Institute of Bioscience and 
      Biotechnology, Daejon 305-333, Republic of Korea.
FAU - Lee, Do Hee
AU  - Lee DH
FAU - Lee, Jung A
AU  - Lee JA
FAU - Park, Sung Goo
AU  - Park SG
FAU - Kim, Nam-Soon
AU  - Kim NS
FAU - Park, Byoung Chul
AU  - Park BC
FAU - Cho, Sayeon
AU  - Cho S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051010
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - EC 3.1.4.43 (Annexin A3)
SB  - IM
MH  - Annexin A3/genetics/*metabolism
MH  - Cell Movement
MH  - Cells, Cultured
MH  - Culture Media, Conditioned/metabolism
MH  - Endothelial Cells/cytology/metabolism
MH  - Gene Expression
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/genetics/metabolism
MH  - *Neovascularization, Physiologic
MH  - Transcriptional Activation/genetics
MH  - Umbilical Veins/cytology/growth & development/metabolism
MH  - Vascular Endothelial Growth Factor A/metabolism
EDAT- 2005/10/21 09:00
MHDA- 2005/12/31 09:00
CRDT- 2005/10/21 09:00
PHST- 2005/09/28 00:00 [received]
PHST- 2005/10/03 00:00 [accepted]
PHST- 2005/10/21 09:00 [pubmed]
PHST- 2005/12/31 09:00 [medline]
PHST- 2005/10/21 09:00 [entrez]
AID - S0006-291X(05)02235-7 [pii]
AID - 10.1016/j.bbrc.2005.10.004 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2005 Dec 2;337(4):1283-7. doi: 
      10.1016/j.bbrc.2005.10.004. Epub 2005 Oct 10.