PMID- 16236269
OWN - NLM
STAT- MEDLINE
DCOM- 20051230
LR  - 20071114
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 337
IP  - 4
DP  - 2005 Dec 2
TI  - Effect of leptin on liver alcohol dehydrogenase.
PG  - 1324-9
AB  - The effect of leptin on liver alcohol dehydrogenase (ADH) was determined in male 
      rats. Administration of one or three daily doses of leptin (1microg/g of body 
      weight intraperitoneally) increased ADH activity. Leptin enhanced ADH synthesis 
      without an effect on ADH degradation. Leptin did not change ADH mRNA, indicating 
      that the effect of leptin in enhancing ADH occurs at the post-transcriptional 
      level. Leptin increased eukaryotic initiation factor (eIF) 2alpha, eIF2B 
      activity, and the eIF4E-eIF4G complex, while it decreased the inhibitory complex 
      of eIF4E with the eIF4E-binding protein-1 (4E-BP1). Leptin increased mammalian 
      target of rapamycin (mTor) that phosphorylates 4E-BP1. In conclusion, leptin 
      increases liver ADH activity and ADH protein due to an increase in synthesis 
      which occurs at the post-transcriptional level. The effect of leptin in enhancing 
      translational initiating factors may be of significance in the regulation not 
      only of ADH but also of many other proteins.
FAU - Mezey, Esteban
AU  - Mezey E
AD  - Department of Medicine, The Johns Hopkins University School of Medicine, 
      Baltimore, MD 21205-2195, USA. emezey@jhmi.edu
FAU - Rennie-Tankersley, Lynda
AU  - Rennie-Tankersley L
FAU - Potter, James J
AU  - Potter JJ
LA  - eng
GR  - AA000626/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20051010
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Leptin)
RN  - EC 1.1.1.1 (Alcohol Dehydrogenase)
SB  - IM
MH  - Alcohol Dehydrogenase/genetics/*metabolism
MH  - Animals
MH  - Leptin/*pharmacology
MH  - Liver/*drug effects/*enzymology
MH  - Male
MH  - Protein Biosynthesis/genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2005/10/21 09:00
MHDA- 2005/12/31 09:00
CRDT- 2005/10/21 09:00
PHST- 2005/09/21 00:00 [received]
PHST- 2005/10/03 00:00 [accepted]
PHST- 2005/10/21 09:00 [pubmed]
PHST- 2005/12/31 09:00 [medline]
PHST- 2005/10/21 09:00 [entrez]
AID - S0006-291X(05)02233-3 [pii]
AID - 10.1016/j.bbrc.2005.10.003 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2005 Dec 2;337(4):1324-9. doi: 
      10.1016/j.bbrc.2005.10.003. Epub 2005 Oct 10.