PMID- 16236599
OWN - NLM
STAT- MEDLINE
DCOM- 20051230
LR  - 20071115
IS  - 0953-7104 (Print)
IS  - 0953-7104 (Linking)
VI  - 16
IP  - 7
DP  - 2005 Nov
TI  - Oxidative stress in blood platelets from schizophrenic patients.
PG  - 386-91
AB  - Oxidative stress in blood platelets is observed in various diseases, including 
      neuropsychiatric disorders. The aim of our study was to evaluate oxidative stress 
      in blood platelets from patients with schizophrenic disorders by measuring the 
      activity of the platelet antioxidative enzyme, superoxide dismutase (SOD), 
      concomitant with the level of thiobarbituric acid reactive species (TBARS). In 
      blood platelets obtained from schizophrenic patients (with paranoid schizophrenia 
      according to DSM-IV criteria) and from healthy volunteers the level of reactive 
      oxygen species was also measured via chemiluminescence. In resting blood 
      platelets from schizophrenic patients the chemiluminescence was higher than in 
      platelets from control subjects (P < 0.05), but in thrombin-activated platelets 
      an increase (about 53%) of chemiluminescence was observed, however this increase 
      was lower than in thrombin-stimulated platelets from healthy subjects (101.5%). 
      The results indicate that in platelets from schizophrenic patients generation of 
      reactive oxygen species is enhanced. Moreover, we observed that SOD activity in 
      blood platelets from schizophrenic patients was significantly lower than in 
      control platelets and that a correlation exists between increased lipid 
      peroxidation and inhibition of the activity of this antioxidative enzyme in 
      schizophrenic platelets.
FAU - Dietrich-Muszalska, A
AU  - Dietrich-Muszalska A
AD  - II Department of Psychiatry, Medical University of Lodz, Poland. tzn_lodz@post.pl
FAU - Olas, B
AU  - Olas B
FAU - Rabe-Jablonska, J
AU  - Rabe-Jablonska J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Platelets
JT  - Platelets
JID - 9208117
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Platelets/chemistry/*metabolism
MH  - Humans
MH  - Oxidation-Reduction
MH  - *Oxidative Stress
MH  - Reactive Oxygen Species/metabolism
MH  - Schizophrenia/*blood/metabolism
MH  - Statistics as Topic
MH  - Superoxide Dismutase/metabolism
MH  - Thiobarbituric Acid Reactive Substances/metabolism
EDAT- 2005/10/21 09:00
MHDA- 2005/12/31 09:00
CRDT- 2005/10/21 09:00
PHST- 2005/10/21 09:00 [pubmed]
PHST- 2005/12/31 09:00 [medline]
PHST- 2005/10/21 09:00 [entrez]
AID - U3QG0Q00232HK027 [pii]
AID - 10.1080/09537100500128872 [doi]
PST - ppublish
SO  - Platelets. 2005 Nov;16(7):386-91. doi: 10.1080/09537100500128872.