PMID- 16237506
OWN - NLM
STAT- MEDLINE
DCOM- 20060613
LR  - 20071115
IS  - 0300-8428 (Print)
IS  - 0300-8428 (Linking)
VI  - 101
IP  - 1
DP  - 2006 Jan
TI  - Granulocyte colony-stimulating factor-induced blood stem cell mobilisation in 
      patients with chronic heart failure--Feasibility, safety and effects on exercise 
      tolerance and cardiac function.
PG  - 78-86
AB  - Bone marrow-derived stem cells may contribute to the regeneration of 
      non-haematopoietic organs. In order to test whether an increase in circulating 
      stem cell numbers improves impaired myocardial function we treated 16 male 
      patients with chronic heart failure due to dilated (DCM; n = 7) or ischaemic 
      cardiomyopathy (ICM; n = 9) with the stem cell mobilising cytokine granulocyte 
      colony-stimulating factor (G-CSF; four 10-day treatment periods interrupted by 
      treatment-free intervals of equal length). Safety and efficacy analyses were 
      performed at regular intervals. Peak CD34+ cell counts remained constant from 
      cycle to cycle. Cardiac side effects in ICM patients included occasional episodes 
      of dyspnea or angina and one episode of fatal ventricular fibrillation. Nine (4 
      DCM, 5 ICM) of 12 patients receiving four full G-CSF cycles experienced an 
      improvement by one New York Heart Association (NYHA) class and a statistically 
      significant increase in six-minute walking distance. By contrast, none of 8 ICM 
      historical controls had a change in NYHA class during a similar time period. 
      Statistically significant changes in echocardiographic parameters were not 
      recorded. Sequential administration of G-CSF is feasible and possibly effective 
      in improving physical performance in patients with chronic heart failure. 
      Patients with ICM may be at risk of increased angina and arrhythmias.
FAU - Huttmann, Andreas
AU  - Huttmann A
AD  - Klinik fur Hamatologie, Universitatsklinikum Essen, Hufelandstrasse 55, 45122 
      Essen, Germany.
FAU - Duhrsen, Ulrich
AU  - Duhrsen U
FAU - Stypmann, Jorg
AU  - Stypmann J
FAU - Noppeney, Richard
AU  - Noppeney R
FAU - Nuckel, Holger
AU  - Nuckel H
FAU - Neumann, Till
AU  - Neumann T
FAU - Gutersohn, Achim
AU  - Gutersohn A
FAU - Nikol, Sigrid
AU  - Nikol S
FAU - Erbel, Raimund
AU  - Erbel R
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20051021
PL  - Germany
TA  - Basic Res Cardiol
JT  - Basic research in cardiology
JID - 0360342
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
SB  - IM
MH  - Aged
MH  - Exercise Test
MH  - Exercise Tolerance
MH  - Granulocyte Colony-Stimulating Factor/adverse effects/*therapeutic use
MH  - Heart Failure/*drug therapy
MH  - Hematopoietic Stem Cell Mobilization/adverse effects/*methods
MH  - Humans
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Patient Compliance
MH  - Treatment Outcome
EDAT- 2005/10/21 09:00
MHDA- 2006/06/14 09:00
CRDT- 2005/10/21 09:00
PHST- 2005/07/14 00:00 [received]
PHST- 2005/09/23 00:00 [accepted]
PHST- 2005/08/29 00:00 [revised]
PHST- 2005/10/21 09:00 [pubmed]
PHST- 2006/06/14 09:00 [medline]
PHST- 2005/10/21 09:00 [entrez]
AID - 10.1007/s00395-005-0556-1 [doi]
PST - ppublish
SO  - Basic Res Cardiol. 2006 Jan;101(1):78-86. doi: 10.1007/s00395-005-0556-1. Epub 
      2005 Oct 21.