PMID- 16237673
OWN - NLM
STAT- MEDLINE
DCOM- 20061129
LR  - 20091119
IS  - 0265-9247 (Print)
IS  - 0265-9247 (Linking)
VI  - 27
IP  - 11
DP  - 2005 Nov
TI  - The synaptic muscle-specific kinase (MuSK) complex: new partners, new functions.
PG  - 1129-35
AB  - The muscle-specific kinase MuSK is part of an agrin receptor complex that 
      stimulates tyrosine phosphorylation and drives clustering of acetylcholine 
      receptors (AChRs) in the postsynaptic membrane at the vertebrate neuromuscular 
      junction (NMJ). MuSK also regulates synaptic gene transcription in subsynaptic 
      nuclei. Over the past few years, decisive progress has been made in the 
      identification of MuSK effectors, helping to understand its function in the 
      formation of the NMJ. Similarly to AChR, MuSK and several of its partners are the 
      target of mutations responsible for diseases of the NMJ, such as congenital 
      myasthenic syndromes. This minireview will focus on the multiple MuSK effectors 
      so far identified that place MuSK at the center of a multifunctional signaling 
      complex involved in the organization of the NMJ and associated disorders.
CI  - Copyright (c) 2005 Wiley Periodicals, Inc.
FAU - Strochlic, Laure
AU  - Strochlic L
AD  - Biologie Cellulaire des Membranes, Institut Jacques Monod, Paris, France.
FAU - Cartaud, Annie
AU  - Cartaud A
FAU - Cartaud, Jean
AU  - Cartaud J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Bioessays
JT  - BioEssays : news and reviews in molecular, cellular and developmental biology
JID - 8510851
RN  - 0 (Receptors, Cholinergic)
RN  - 21820-51-9 (Phosphotyrosine)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Animals
MH  - Phosphotyrosine/metabolism
MH  - Protein Binding
MH  - Receptor Protein-Tyrosine Kinases/genetics/immunology/*metabolism
MH  - Receptors, Cholinergic/genetics/immunology/*metabolism
MH  - Signal Transduction
MH  - Synapses/genetics/immunology/*metabolism
RF  - 63
EDAT- 2005/10/21 09:00
MHDA- 2006/12/09 09:00
CRDT- 2005/10/21 09:00
PHST- 2005/10/21 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2005/10/21 09:00 [entrez]
AID - 10.1002/bies.20305 [doi]
PST - ppublish
SO  - Bioessays. 2005 Nov;27(11):1129-35. doi: 10.1002/bies.20305.