PMID- 16241270
OWN - NLM
STAT- MEDLINE
DCOM- 20060104
LR  - 20051024
IS  - 1539-3755 (Print)
IS  - 1539-3755 (Linking)
VI  - 67
IP  - 6 Pt 1
DP  - 2003 Jun
TI  - Classification of short human exons and introns based on statistical features.
PG  - 061916
AB  - The classification of human gene sequences into exons and introns is a difficult 
      problem in DNA sequence analysis. In this paper, we define a set of features, 
      called the simple Z (SZ) features, which is derived from the Z-curve features for 
      the recognition of human exons and introns. The classification results show that 
      SZ features, while fewer in numbers (three in total), can preserve the high 
      recognition rate of the original nine Z-curve features. Since the size of SZ 
      features is one-third of the Z-curve features, the dimensionality of the feature 
      space is much smaller, and better recognition efficiency is achieved. If the stop 
      codon feature is used together with the three SZ features, a recognition rate of 
      up to 92% for short sequences of length <140 bp can be obtained.
FAU - Wu, Yonghui
AU  - Wu Y
AD  - Department of Computer Engineering and Information Technology, City University of 
      Hong Kong, Kowloon, Hong Kong. itwyh@cityu.edu.hk
FAU - Liew, Alan Wee-Chung
AU  - Liew AW
FAU - Yan, Hong
AU  - Yan H
FAU - Yang, Mengsu
AU  - Yang M
LA  - eng
PT  - Journal Article
DEP - 20030627
PL  - United States
TA  - Phys Rev E Stat Nonlin Soft Matter Phys
JT  - Physical review. E, Statistical, nonlinear, and soft matter physics
JID - 101136452
RN  - 0 (Codon)
RN  - 0 (Codon, Terminator)
SB  - IM
MH  - Algorithms
MH  - Biophysics/methods
MH  - Codon
MH  - Codon, Terminator
MH  - Computational Biology/*methods
MH  - *Exons
MH  - Humans
MH  - *Introns
MH  - *Models, Genetic
MH  - Models, Statistical
MH  - Sequence Analysis, DNA/*methods
EDAT- 2005/10/26 09:00
MHDA- 2006/01/05 09:00
CRDT- 2005/10/26 09:00
PHST- 2002/10/07 00:00 [received]
PHST- 2005/10/26 09:00 [pubmed]
PHST- 2006/01/05 09:00 [medline]
PHST- 2005/10/26 09:00 [entrez]
AID - 10.1103/PhysRevE.67.061916 [doi]
PST - ppublish
SO  - Phys Rev E Stat Nonlin Soft Matter Phys. 2003 Jun;67(6 Pt 1):061916. doi: 
      10.1103/PhysRevE.67.061916. Epub 2003 Jun 27.