PMID- 16242642
OWN - NLM
STAT- MEDLINE
DCOM- 20060123
LR  - 20161124
IS  - 0969-9961 (Print)
IS  - 0969-9961 (Linking)
VI  - 20
IP  - 2
DP  - 2005 Nov
TI  - Progressive neurodegeneration in C. elegans model of tauopathy.
PG  - 372-83
AB  - Discovery of various mutations in the tau gene among frontotemporal dementia and 
      parkinsonism linked to chromosome 17 (FTDP-17) families suggests gain-of-toxic 
      function of wild-type or mutant tau as the mechanism for extensive neuronal loss. 
      We thus generated transgenic nematode (Caenorhabditis elegans) expressing 
      wild-type or mutant (P301L and R406W) tau in the touch (mechanosensory) neurons. 
      Whereas the worm expressing wild-type tau showed a small decrease in the touch 
      response across the lifespan, the worm expressing mutant tau displayed a large 
      and progressive decrease. When the touch neurons lost their function, neuritic 
      abnormalities were found prominent, and microtubular loss became remarkable in 
      the later stage. A substantial fraction of degenerating neurons developed tau 
      accumulation in the cell body and neuronal processes. This neuronal dysfunction 
      is not related to the apoptotic process because little recovery from touch 
      abnormality was observed in the ced-3 or ced-4-deficient background. Expression 
      of GSK3 brought about slight deterioration in the touch response, while 
      expression of HSP70 led to some improvement.
FAU - Miyasaka, Tomohiro
AU  - Miyasaka T
AD  - Department of Neuropathology, Faculty of Medicine, University of Tokyo, 7-3-1 
      Hongo, Tokyo 113-0033, Japan.
FAU - Ding, Zhen
AU  - Ding Z
FAU - Gengyo-Ando, Keiko
AU  - Gengyo-Ando K
FAU - Oue, Miho
AU  - Oue M
FAU - Yamaguchi, Haruyasu
AU  - Yamaguchi H
FAU - Mitani, Shohei
AU  - Mitani S
FAU - Ihara, Yasuo
AU  - Ihara Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurobiol Dis
JT  - Neurobiology of disease
JID - 9500169
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (tau Proteins)
RN  - EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta)
RN  - EC 2.7.11.26 (Glycogen Synthase Kinase 3)
SB  - IM
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Caenorhabditis elegans/genetics/*metabolism
MH  - Disease Models, Animal
MH  - Glycogen Synthase Kinase 3/genetics/metabolism
MH  - Glycogen Synthase Kinase 3 beta
MH  - HSP70 Heat-Shock Proteins/genetics/metabolism
MH  - Immunohistochemistry
MH  - Mechanoreceptors/metabolism/pathology/ultrastructure
MH  - Microscopy, Electron, Transmission
MH  - Microtubules/metabolism/pathology/ultrastructure
MH  - Mutation/genetics
MH  - Nerve Degeneration/*metabolism/pathology/physiopathology
MH  - Nervous System/*metabolism/pathology/physiopathology
MH  - Neurites/metabolism/pathology/ultrastructure
MH  - Neurons/metabolism/pathology/ultrastructure
MH  - Oxidative Stress/genetics
MH  - Somatosensory Disorders/metabolism/pathology/physiopathology
MH  - Tauopathies/*metabolism/pathology/physiopathology
MH  - Touch/genetics
MH  - tau Proteins/genetics/metabolism
EDAT- 2005/10/26 09:00
MHDA- 2006/01/24 09:00
CRDT- 2005/10/26 09:00
PHST- 2004/08/11 00:00 [received]
PHST- 2005/02/02 00:00 [revised]
PHST- 2005/03/08 00:00 [accepted]
PHST- 2005/10/26 09:00 [pubmed]
PHST- 2006/01/24 09:00 [medline]
PHST- 2005/10/26 09:00 [entrez]
AID - S0969-9961(05)00079-3 [pii]
AID - 10.1016/j.nbd.2005.03.017 [doi]
PST - ppublish
SO  - Neurobiol Dis. 2005 Nov;20(2):372-83. doi: 10.1016/j.nbd.2005.03.017.