PMID- 16244857
OWN - NLM
STAT- MEDLINE
DCOM- 20061201
LR  - 20081121
IS  - 0340-5761 (Print)
IS  - 0340-5761 (Linking)
VI  - 80
IP  - 5
DP  - 2006 May
TI  - Developmental and neurobehavioral effects of perinatal exposure to 
      polychlorinated biphenyls in mice.
PG  - 286-92
AB  - Because behavioral deficits associated with gestational exposure to 
      polychlorinated biphenyls (PCBs) have been a concern, we studied the 
      developmental and neurobehavioral effects of perinatal exposure to Aroclor 1254 
      (A1254), a commercial mixture of PCBs, in mice. The PCB mixture (A1254; 0, 6, 18, 
      and 54 mg/kg body weight) was administered to pregnant mice (C57BL/6Cr) every 3 
      days by gavage from gestational day (GD) 6 to postnatal day (PND) 20. Compared 
      with the control, treatment with A1254 did not alter the maternal body weight 
      during the gestation and lactation periods. The body weight of the offspring did 
      not differ among treatments. To assess the effects on offspring following such 
      exposure, physical and neurobehavioral development (i.e., pinna detachment, hair 
      growth, eye opening, incisor eruption, grasp reflex, righting reflex, walking, 
      negative geotaxis, and cliff avoidance) was observed before weaning. At PND 7, 
      poor adult-like responses in negative geotaxis were observed in all exposed 
      groups. When the offspring were at 8-week old, the PCB-treated (18 mg/kg body 
      weight) mice showed a decreased walking speed in the open-field test, and a 
      prolonged time to reach the platform in the water maze test. Spontaneous 
      locomotion activity was not affected by PCB exposure at 9 weeks . These results 
      showed that perinatal exposure to PCBs produces several behavioral alterations in 
      mice. Although dose-dependent changes were not observed, the neurobehavioral 
      effects such as a decreased walking speed in the open-field test and a prolonged 
      time to reach the platform in the water maze test remained in adulthood after the 
      seeming recovery from the transient delay in development before weaning.
FAU - Sugawara, Norio
AU  - Sugawara N
AD  - Department of Environmental Health Sciences, Tohoku University Graduate School of 
      Medicine, 2-1 Seiryomachi, Aoba-ku, Sendai, 980-8575, Japan. 
      nsuga@ehs.med.tohoku.ac.jp
FAU - Nakai, Kunihiko
AU  - Nakai K
FAU - Nakamura, Tomoyuki
AU  - Nakamura T
FAU - Ohba, Takashi
AU  - Ohba T
FAU - Suzuki, Keita
AU  - Suzuki K
FAU - Kameo, Satomi
AU  - Kameo S
FAU - Satoh, Chieko
AU  - Satoh C
FAU - Satoh, Hiroshi
AU  - Satoh H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051022
PL  - Germany
TA  - Arch Toxicol
JT  - Archives of toxicology
JID - 0417615
RN  - 11097-69-1 (Chlorodiphenyl (54% Chlorine))
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Behavior, Animal/*drug effects
MH  - Body Weight/drug effects
MH  - Chlorodiphenyl (54% Chlorine)/*toxicity
MH  - Female
MH  - Growth/drug effects
MH  - Lactation/drug effects
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Maze Learning/drug effects
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Motor Activity/drug effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Reflex/drug effects
MH  - Time Factors
EDAT- 2005/10/26 09:00
MHDA- 2006/12/09 09:00
CRDT- 2005/10/26 09:00
PHST- 2005/07/12 00:00 [received]
PHST- 2005/09/28 00:00 [accepted]
PHST- 2005/10/26 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2005/10/26 09:00 [entrez]
AID - 10.1007/s00204-005-0042-4 [doi]
PST - ppublish
SO  - Arch Toxicol. 2006 May;80(5):286-92. doi: 10.1007/s00204-005-0042-4. Epub 2005 
      Oct 22.