PMID- 16248506
OWN - NLM
STAT- MEDLINE
DCOM- 20110404
LR  - 20171116
VI  - 19
IP  - 15
DP  - 2005 Aug
TI  - [Expression and significance of CD44v6 and MMP-9 in laryngeal squamous cell 
      carcinoma].
PG  - 688-91
AB  - OBJECTIVE: To investigate the clinical implication and the expression of CD44v6 
      and MMP-9 protein in laryngeal squamous cell carcinoma (LSCC). METHOD: 
      Twenty-seven samples of LSCC and eight biopsies of adjacent non-cancerous tissue 
      were detected with immunohistochemical technique (SABC method). The relationship 
      between positive expression of CD44v6 or MMP-9 in LSCC and invasion or metastasis 
      was analyzed. RESULT: Both CD44v6 and MMP-9 overexpressed in LSCC. The positive 
      expression of CD44v6 was correlated with LSCC pathologic grade, cervical lymph 
      node metastasis and postoperation survival rate (P < 0.05). The expression of 
      MMP-9 was positively correlated with clinical staging and cervical lymph node 
      metastasis (P < 0.05). There was a significant positive correlation between the 
      expression of CD44v6 and MMP-9 (P < 0.01). CONCLUSION: There is a relationship 
      between the expression of CD44 and MMP-9. CD44v6 and MMP-9 might be served as an 
      objective indicator for lymph nodal metastatic potency, tumor invasion and 
      prognosis in LSCC.
FAU - Qin, Gang
AU  - Qin G
AD  - Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Luzhou 
      Medical College, Luzhou, 646000, China. qin-lzm@tom.com
FAU - Li, Wanrong
AU  - Li W
FAU - Sun, Xingwang
AU  - Sun X
FAU - Zhu, Lin
AU  - Zhu L
FAU - Chen, Zhengnong
AU  - Chen Z
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (CD44v6 antigen)
RN  - 0 (Hyaluronan Receptors)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Hyaluronan Receptors/*metabolism
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Matrix Metalloproteinase 9/*metabolism
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
EDAT- 2005/10/27 09:00
MHDA- 2011/04/05 06:00
CRDT- 2005/10/27 09:00
PHST- 2005/10/27 09:00 [pubmed]
PHST- 2011/04/05 06:00 [medline]
PHST- 2005/10/27 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Aug;19(15):688-91.