PMID- 16249100
OWN - NLM
STAT- MEDLINE
DCOM- 20060329
LR  - 20161124
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 29
IP  - 3
DP  - 2006 Feb 1
TI  - Association of neural and physiological responses during voluntary emotion 
      suppression.
PG  - 721-33
AB  - Recent neuroimaging studies have shown that several prefrontal regions play 
      critical roles in inhibiting activation of limbic regions during voluntary 
      emotion regulation. The present study aimed to confirm prior findings and to 
      extend them by identifying the frontal neural circuitry associated with 
      regulation of peripheral physiological responses during voluntary emotion 
      suppression. Ten healthy female subjects were presented with affectively 
      positive, neutral, and negative pictures in each of an Attending and Suppression 
      task. Regional cerebral blood-flow changes were measured using 15O-water positron 
      emission tomography, and autonomic (heart rate: HR, skin conductance response: 
      SCR) and endocrine (adrenocorticotropic hormone: ACTH) indices were measured 
      during both tasks. The left amygdala and the right anterior temporal pole were 
      activated during the Attending task, whereas activation was observed in the left 
      lateral prefrontal cortex (LPFC), including the adjacent medial prefrontal cortex 
      (MPFC), and medial orbitofrontal cortex (MOFC) during the Suppression task. In 
      the Attending task, activation in the amygdala and MOFC positively correlated 
      with magnitudes of the SCR and ACTH responses. Emotion suppression elicited 
      enhancement of SCR and the strength of the effect positively correlated with 
      activation in the MOFC. These results suggest that the MOFC plays a pivotal role 
      in top-down regulation of peripheral physiological responses accompanying 
      emotional experiences.
FAU - Ohira, Hideki
AU  - Ohira H
AD  - Department of Psychology, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 
      464-8601 Japan. ohira@lit.nagoya-u.ac.jp
FAU - Nomura, Michio
AU  - Nomura M
FAU - Ichikawa, Naho
AU  - Ichikawa N
FAU - Isowa, Tokiko
AU  - Isowa T
FAU - Iidaka, Tetsuya
AU  - Iidaka T
FAU - Sato, Atsushi
AU  - Sato A
FAU - Fukuyama, Seisuke
AU  - Fukuyama S
FAU - Nakajima, Toshihiko
AU  - Nakajima T
FAU - Yamada, Jitsuhiro
AU  - Yamada J
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051024
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
RN  - 0 (Oxygen Radioisotopes)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood
MH  - Adult
MH  - Amygdala/blood supply/diagnostic imaging/physiology
MH  - Attention/physiology
MH  - Autonomic Nervous System/physiology
MH  - Brain/diagnostic imaging/*physiology
MH  - Cerebrovascular Circulation/physiology
MH  - Data Interpretation, Statistical
MH  - Emotions/*physiology
MH  - Female
MH  - Galvanic Skin Response/physiology
MH  - Heart Rate/physiology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Limbic System/blood supply/diagnostic imaging/physiology
MH  - Nerve Net/*physiology
MH  - Oxygen Radioisotopes
MH  - Photic Stimulation
MH  - Positron-Emission Tomography
MH  - Prefrontal Cortex/blood supply/diagnostic imaging/physiology
MH  - Temporal Lobe/blood supply/diagnostic imaging/physiology
EDAT- 2005/10/27 09:00
MHDA- 2006/03/30 09:00
CRDT- 2005/10/27 09:00
PHST- 2004/12/01 00:00 [received]
PHST- 2005/08/06 00:00 [revised]
PHST- 2005/08/15 00:00 [accepted]
PHST- 2005/10/27 09:00 [pubmed]
PHST- 2006/03/30 09:00 [medline]
PHST- 2005/10/27 09:00 [entrez]
AID - S1053-8119(05)00603-8 [pii]
AID - 10.1016/j.neuroimage.2005.08.047 [doi]
PST - ppublish
SO  - Neuroimage. 2006 Feb 1;29(3):721-33. doi: 10.1016/j.neuroimage.2005.08.047. Epub 
      2005 Oct 24.