PMID- 16249810
OWN - NLM
STAT- MEDLINE
DCOM- 20051215
LR  - 20071115
IS  - 0025-0244 (Print)
IS  - 0025-0244 (Linking)
VI  - 49
IP  - 2
DP  - 2005
TI  - [Identification of 3q21q26 syndrome by "multipoint" interphase FISH analyses in 
      childhood myeloid leukemia].
PG  - 141-7
AB  - Cytogenetic syndrome involving bands 3q21 and 3q26, known as "3q21q26 syndrome" 
      has been observed in adult patients with acute myelogenous leukemia (0.5-2%), 
      chronic myelogenous leukemia in blast crisis (20%), myelodysplastic syndromes and 
      myeloproliferative disorders. In the present study bone marrow samples from two 
      boys (12 and 16 years), diagnosed with CML and AML respectively, were 
      investigated using conventional cytogenetic methods, interphase "multipoint" 
      fluorescence in situ hybridization (FISH), dual color-FISH and multiplex FISH. 
      The "multipoint" FISH analysis identified in de novo childhood AML case an 
      inv(3)(q21q26) and a complex 3q rearrangement including inversion and duplication 
      in the CML case. The "3q21q26 syndrome" is associated with normal or elevated 
      platelet counts with marked abnormalities of megakaryocytopoiesis, involvement of 
      multiple hematopoietic lineages. The affected patients were resistant to 
      conventional chemotherapy and had a short survival. This syndrome is very rare in 
      de novo childhood AML, and simultaneous presence of 3q inversion and duplication, 
      to our knowledge, has not yet been identified in hematological malignancies. The 
      results of our study emphasize the importance of classical and modern cytogenetic 
      analysis in the diagnosis of hematologic malignancies, because in the majority of 
      cases they can provide additional diagnostic information for the clinicians in 
      deciding the best therapeutic approach, precise classification and prognosis of 
      the disease.
FAU - Haltrich, Iren
AU  - Haltrich I
AD  - II.sz Gyermekgyogyaszati Klinika, Semmelweis Egyetem, Altalanos Orvostudomanyi 
      Kar, Budapest 1094, Hungary. Haltrich@gyer2.sote.hu
FAU - Kost-Alimova, Maria
AU  - Kost-Alimova M
FAU - Kovacs, Gabor
AU  - Kovacs G
FAU - Krivan, Gergely
AU  - Krivan G
FAU - Dobos, Matild
AU  - Dobos M
FAU - Imreh, Stefan
AU  - Imreh S
FAU - Fekete, Gyorgy
AU  - Fekete G
LA  - hun
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - A "3q21q26-szindroma" azonositasa sokpontos interfazis-FISH vizsgalattal 
      gyermekkori myeloid leukaemiaban.
DEP - 20051024
PL  - Hungary
TA  - Magy Onkol
JT  - Magyar onkologia
JID - 9313833
SB  - IM
MH  - Adolescent
MH  - Bone Marrow
MH  - Child
MH  - *Chromosomes, Human, Pair 3
MH  - Gene Duplication
MH  - *Gene Rearrangement
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence/methods
MH  - Leukemia, Myeloid, Acute/*diagnosis/*genetics
MH  - Male
MH  - Syndrome
EDAT- 2005/10/27 09:00
MHDA- 2005/12/16 09:00
CRDT- 2005/10/27 09:00
PHST- 2005/03/04 00:00 [received]
PHST- 2005/03/31 00:00 [accepted]
PHST- 2005/10/27 09:00 [pubmed]
PHST- 2005/12/16 09:00 [medline]
PHST- 2005/10/27 09:00 [entrez]
PST - ppublish
SO  - Magy Onkol. 2005;49(2):141-7. Epub 2005 Oct 24.