PMID- 16250860
OWN - NLM
STAT- MEDLINE
DCOM- 20060123
LR  - 20191109
IS  - 1568-0169 (Print)
IS  - 1568-0169 (Linking)
VI  - 3
IP  - 4
DP  - 2005 Oct
TI  - Homocysteine-lowering treatment in coronary heart disease.
PG  - 289-95
AB  - Homocysteine (Hcy) is a sulphur-containing amino acid product of methionine's 
      metabolism. Hyperhomocysteinemia (HHcy) is considered an independent risk factor 
      for cardiovascular (CV) disease, at least in high-risk patients. In fact, 
      evidence indicates that although mild HHcy may be regarded as a minor risk factor 
      for CHD in low-risk patients, it can play a role in triggering new events in 
      patients with known CHD, also by interacting with the "classical" CV risk 
      factors. This is of much interest because HHcy represents a correctable risk 
      factor, inasmuch vitamin supplementation as has been shown to effectively lower 
      total homocysteine plasma levels (tHcy). While case-control and cross-sectional 
      studies have consistently demonstrated an association of HHcy with CV disease, 
      prospective studies have given conflicting results. Moreover, the effect of the 
      homocysteine-lowering treatment in preventing CV events is still under debate. 
      Thus, it remains unclear which patients should be screened for HHcy and which 
      ones should be treated to lower tHcy. In this paper we shall report and discuss 
      knowledge on the potential role of HHcy in the development of CHD and on the 
      benefits due to tHcy-lowering treatment with vitamins.
FAU - Cesari, M
AU  - Cesari M
AD  - Department of Clinical & Experimental Medicine, Clinica Medica 4, University of 
      Padova, Italy. mcesari@hotmail.com
FAU - Rossi, G P
AU  - Rossi GP
FAU - Pessina, A C
AU  - Pessina AC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Med Chem Cardiovasc Hematol Agents
JT  - Current medicinal chemistry. Cardiovascular and hematological agents
JID - 101157213
RN  - 0 (Vitamins)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Coronary Disease/*blood/physiopathology
MH  - Female
MH  - Folic Acid/administration & dosage
MH  - Homocysteine/*blood/physiology
MH  - Humans
MH  - Kidney Failure, Chronic/blood
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Vitamins/administration & dosage
RF  - 101
EDAT- 2005/10/28 09:00
MHDA- 2006/01/24 09:00
CRDT- 2005/10/28 09:00
PHST- 2005/10/28 09:00 [pubmed]
PHST- 2006/01/24 09:00 [medline]
PHST- 2005/10/28 09:00 [entrez]
AID - 10.2174/156801605774322319 [doi]
PST - ppublish
SO  - Curr Med Chem Cardiovasc Hematol Agents. 2005 Oct;3(4):289-95. doi: 
      10.2174/156801605774322319.