PMID- 16251607
OWN - NLM
STAT- MEDLINE
DCOM- 20060203
LR  - 20230216
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 135
IP  - 11
DP  - 2005 Nov
TI  - The apolipoprotein E gene promoter (-219G/T) polymorphism determines insulin 
      sensitivity in response to dietary fat in healthy young adults.
PG  - 2535-40
AB  - Insulin sensitivity (IS) is determined by genetic and environmental factors, 
      including diet. The apoE gene promoter -219G/T polymorphism is associated with 
      coronary heart disease and increased postprandial triacylglycerol-rich 
      lipoprotein concentration, circumstances related to insulin resistance. Thus, our 
      aim was to determine whether this polymorphism modified the IS response to 
      dietary fat in healthy young adults. Volunteers (n = 43) with the apoE3/E3 
      genotype (8 GG, 25 GT and 10 TT) completed 3 dietary periods, each lasting 4 wk. 
      They first consumed a SFA-rich diet [38% fat (% of energy in the total diet), 20% 
      SFA (% of energy in the total diet)], and then, in a randomized, crossover 
      design, a carbohydrate (CHO)-rich diet (30% fat, 55% CHO) or a monounsaturated 
      fatty acid (MUFA)-rich diet (38% fat, 22% MUFA). After each diet period, we 
      investigated peripheral IS using the insulin suppression test. The steady-state 
      plasma glucose (SSPG) concentration was lower (P < 0.05) in GG subjects than in 
      GT and TT individuals, regardless of the diet consumed. Significant diet x 
      genotype interactions were found for SSPG and plasma nonesterified FFA (NEFA) 
      concentrations. Thus, the shift from the SFA-rich diet to the MUFA- or CHO-rich 
      diets decreased (P < 0.05) the SSPG and NEFA concentrations in GG and GT, but not 
      in TT subjects. In conclusion, carriers of the -219T allele are less insulin 
      sensitive than GG individuals. Furthermore, only carriers of the -219G allele 
      have improved IS when MUFA- or CHO-rich diets are consumed instead of a SFA-rich 
      diet.
FAU - Moreno, Juan Antonio
AU  - Moreno JA
AD  - Lipids and Atherosclerosis Research Unit, Hospital Universitario Reina Sofia, 
      Cordoba, Spain.
FAU - Perez-Jimenez, Francisco
AU  - Perez-Jimenez F
FAU - Marin, Carmen
AU  - Marin C
FAU - Perez-Martinez, Pablo
AU  - Perez-Martinez P
FAU - Moreno, Rafael
AU  - Moreno R
FAU - Gomez, Purificacion
AU  - Gomez P
FAU - Jimenez-Gomez, Yolanda
AU  - Jimenez-Gomez Y
FAU - Paniagua, Juan Antonio
AU  - Paniagua JA
FAU - Lairon, Denis
AU  - Lairon D
FAU - Lopez-Miranda, Jose
AU  - Lopez-Miranda J
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Apolipoproteins E)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Apolipoproteins E/*genetics
MH  - Cholesterol, LDL/blood
MH  - Cross-Over Studies
MH  - Dietary Carbohydrates/administration & dosage
MH  - Dietary Fats/*administration & dosage
MH  - Energy Intake
MH  - Fasting
MH  - Fatty Acids/administration & dosage
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Insulin/blood/*pharmacology
MH  - Male
MH  - Polymorphism, Genetic/*genetics
MH  - Promoter Regions, Genetic/*genetics
EDAT- 2005/10/28 09:00
MHDA- 2006/02/04 09:00
CRDT- 2005/10/28 09:00
PHST- 2005/10/28 09:00 [pubmed]
PHST- 2006/02/04 09:00 [medline]
PHST- 2005/10/28 09:00 [entrez]
AID - S0022-3166(22)10460-8 [pii]
AID - 10.1093/jn/135.11.2535 [doi]
PST - ppublish
SO  - J Nutr. 2005 Nov;135(11):2535-40. doi: 10.1093/jn/135.11.2535.