PMID- 16253630
OWN - NLM
STAT- MEDLINE
DCOM- 20051228
LR  - 20131121
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 54
IP  - 11
DP  - 2005 Nov
TI  - Genome-wide search for genes affecting serum uric acid levels: the Framingham 
      Heart Study.
PG  - 1435-41
AB  - Serum uric acid levels are associated with hypertension, cardiovascular disease, 
      and renal disease. Uric acid has been shown to be heritable; however, genome-wide 
      linkage analyses have not been reported. Genome-wide multipoint variance 
      components linkage analyses with 401 markers spaced at approximately 10 
      centimorgan (cM) were conducted on 1258 subjects of the Framingham Heart Study, 
      using the average of two serum uric acid measurements obtained in examinations 1 
      and 2 around 1971 and 1979. Covariates in fully adjusted model included sex, age, 
      body mass index (BMI), serum creatinine, alcohol consumption, diabetes, diuretic 
      treatment, and triglycerides. To investigate possible pleiotropic effects between 
      uric acid and covariates that may have a genetic component, bivariate linkage 
      analyses of uric acid with BMI, triglycerides, and glucose were conducted at the 
      uric acid linkage regions. The heritability of uric acid was 0.63. The highest 
      multipoint log-of-the-odds (LOD) score was 3.3 at 50 cM on chromosome 15 for 
      age-sex-adjusted uric acid, but decreased to 1.5 after multivariable adjustment. 
      Additional evidence of linkage was seen on chromosomes 2 (LOD score 1.1 at 4 cM) 
      and 8 (LOD score 1.7 at 6 cM) for multivariable-adjusted uric acid. Pleiotropic 
      effects were only found between uric acid and glucose and BMI at chromosomes 8 
      and 15 linkage locations, respectively. We have identified several novel loci 
      linked to uric acid. We found possible pleiotropic effects between uric acid and 
      BMI and glucose. Further research is necessary to identify the genes involved in 
      uric acid metabolism and their roles in hypertension, cardiovascular disease, and 
      renal disease.
FAU - Yang, Qiong
AU  - Yang Q
AD  - Department of Biostatistics, Boston University School of Public Health, Boston, 
      MA 02118, USA. qyang@bu.edu
FAU - Guo, Chao-Yu
AU  - Guo CY
FAU - Cupples, L Adrienne
AU  - Cupples LA
FAU - Levy, Daniel
AU  - Levy D
FAU - Wilson, Peter W F
AU  - Wilson PW
FAU - Fox, Caroline S
AU  - Fox CS
LA  - eng
GR  - N01-HC-25195/HC/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Adult
MH  - Cardiovascular Diseases/*genetics/*metabolism
MH  - *Chromosomes, Human
MH  - Chromosomes, Human, Pair 15
MH  - Chromosomes, Human, Pair 2
MH  - Chromosomes, Human, Pair 8
MH  - Cohort Studies
MH  - Female
MH  - Genetic Linkage
MH  - *Genome, Human
MH  - Genomics
MH  - Humans
MH  - Male
MH  - Massachusetts
MH  - Middle Aged
MH  - Uric Acid/*blood
EDAT- 2005/10/29 09:00
MHDA- 2005/12/29 09:00
CRDT- 2005/10/29 09:00
PHST- 2004/11/12 00:00 [received]
PHST- 2005/05/19 00:00 [accepted]
PHST- 2005/10/29 09:00 [pubmed]
PHST- 2005/12/29 09:00 [medline]
PHST- 2005/10/29 09:00 [entrez]
AID - S0026-0495(05)00215-5 [pii]
AID - 10.1016/j.metabol.2005.05.007 [doi]
PST - ppublish
SO  - Metabolism. 2005 Nov;54(11):1435-41. doi: 10.1016/j.metabol.2005.05.007.