PMID- 16253900
OWN - NLM
STAT- MEDLINE
DCOM- 20060127
LR  - 20220409
IS  - 1521-6918 (Print)
IS  - 1521-6918 (Linking)
VI  - 19
IP  - 5
DP  - 2005 Oct
TI  - Insulinoma.
PG  - 783-98
AB  - Although rare, insulinomas are the most common functioning islet cell tumour of 
      the pancreas. Recognition of the key neuroglycopenic symptoms should trigger the 
      initial investigation. Biochemical proof of endogenous hyperinsulinemic 
      hypoglycemia establishes the diagnosis. Several options are available for imaging 
      and localizing these tumours including ultrasonography, computed tomography, and 
      intra-arterial calcium stimulation with venous sampling. The tumours are usually 
      small, single, benign, well-circumscribed, and evenly distributed throughout the 
      pancreas. This tumour may be a part of the multiple endocrine neoplasia type 1 
      (MEN-1) syndrome, in which case the tumours are almost always multiple. Surgical 
      treatment is the only curative method, traditionally accomplished with 
      enucleation or partial pancreatic resection. Patients are almost invariably cured 
      lifelong with complete excision of a benign insulinoma. The most recent 
      developments in this area are the recognition of noninsulinoma pancreatogenous 
      hypoglycemia syndrome as a cause of organic hypoglycemia, and the development of 
      laparoscopic techniques to excise these tumours.
FAU - Grant, Clive S
AU  - Grant CS
AD  - Department of Surgery, Mayo Clinic College of Medicine, Mayo Clinic, 200 First 
      Street, SW Rochester, MN 55905, USA. cgrant@mayo.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Best Pract Res Clin Gastroenterol
JT  - Best practice & research. Clinical gastroenterology
JID - 101120605
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - Biopsy, Needle
MH  - Endosonography/methods
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Incidence
MH  - Insulinoma/*diagnosis/epidemiology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Pancreatectomy/*methods
MH  - Pancreatic Neoplasms/*diagnosis/epidemiology/*surgery
MH  - Phlebography/methods
MH  - Prognosis
MH  - Rare Diseases
MH  - Risk Assessment
MH  - Sex Distribution
MH  - Survival Rate
MH  - Tomography, X-Ray Computed/methods
MH  - Treatment Outcome
RF  - 52
EDAT- 2005/10/29 09:00
MHDA- 2006/01/28 09:00
CRDT- 2005/10/29 09:00
PHST- 2005/10/29 09:00 [pubmed]
PHST- 2006/01/28 09:00 [medline]
PHST- 2005/10/29 09:00 [entrez]
AID - S1521-6918(05)00094-6 [pii]
AID - 10.1016/j.bpg.2005.05.008 [doi]
PST - ppublish
SO  - Best Pract Res Clin Gastroenterol. 2005 Oct;19(5):783-98. doi: 
      10.1016/j.bpg.2005.05.008.