PMID- 16253901
OWN - NLM
STAT- MEDLINE
DCOM- 20060127
LR  - 20061115
IS  - 1521-6918 (Print)
IS  - 1521-6918 (Linking)
VI  - 19
IP  - 5
DP  - 2005 Oct
TI  - Surgical treatment and prognosis of gastrinoma.
PG  - 799-805
AB  - Zollinger-Ellison syndrome (ZES) is a clinical syndrome with severe peptic ulcer 
      disease and diarrhea caused by gastric acid hypersecretion secondary to a 
      neuroendocrine tumour that secretes excessive amounts of the hormone gastrin 
      (gastrinoma). Gastrinomas occur in a familial and a sporadic form. Patients with 
      gastrinoma in the familial setting of Multiple Endocrine Neoplasia type 1 (MEN-1) 
      are seldom, if ever, cured of Zollinger-Ellison syndrome by the current 
      non-Whipple operations to remove duodenal and pancreatic gastrinoma. Surgery is 
      currently used in these patients to deal with the malignant nature of pancreatic 
      or duodenal neuroendocrine tumours. Malignant potential is best determined by 
      tumour size. Tumours that are greater than 2 cm in size should be excised. In the 
      sporadic setting, cure occurs in a significant proportion of patients (50%) by 
      surgical resection of gastrinoma. Duodenotomy has improved both the tumour 
      detection rate and the cure rate and should be routinely done. Whipple 
      pancreaticoduodenectomy results in the highest probability of cure in both 
      sporadic and MEN-1 gastrinoma patients as it removes the entire gastrinoma 
      triangle. However, the excellent long-term survival of these patients with lesser 
      operations and the increased operative mortality and long-term morbidity of 
      Whipple make its current role unclear until further studies are done.
FAU - Norton, Jeffrey A
AU  - Norton JA
AD  - Department of Surgery, Stanford University Medical Center, Room H3591, 300 
      Pasteur Drive, Stanford, CA 94305-5641, USA.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Best Pract Res Clin Gastroenterol
JT  - Best practice & research. Clinical gastroenterology
JID - 101120605
SB  - IM
MH  - Female
MH  - Gastrinoma/*mortality/pathology/*surgery
MH  - Humans
MH  - Male
MH  - Neoplasm Staging
MH  - Pancreatectomy/*methods
MH  - Pancreatic Neoplasms/*mortality/pathology/*surgery
MH  - Pancreaticoduodenectomy/methods
MH  - Prognosis
MH  - Risk Assessment
MH  - Survival Analysis
MH  - Treatment Outcome
MH  - Zollinger-Ellison Syndrome/mortality/pathology/surgery
RF  - 49
EDAT- 2005/10/29 09:00
MHDA- 2006/01/28 09:00
CRDT- 2005/10/29 09:00
PHST- 2005/10/29 09:00 [pubmed]
PHST- 2006/01/28 09:00 [medline]
PHST- 2005/10/29 09:00 [entrez]
AID - S1521-6918(05)00088-0 [pii]
AID - 10.1016/j.bpg.2005.05.003 [doi]
PST - ppublish
SO  - Best Pract Res Clin Gastroenterol. 2005 Oct;19(5):799-805. doi: 
      10.1016/j.bpg.2005.05.003.