PMID- 1625506
OWN - NLM
STAT- MEDLINE
DCOM- 19920807
LR  - 20131121
IS  - 0379-0355 (Print)
IS  - 0379-0355 (Linking)
VI  - 14
IP  - 3
DP  - 1992 Apr
TI  - Intracerebroventricular endothelin-1 (ET-1) produces Ca(2+)-mediated 
      antinociception in mice.
PG  - 229-33
AB  - Intracerebroventricular (i.c.v.) administration of endothelin-1 (ET-1) at doses 
      of 0.313, 0.625, 1.25, 2.5 and 5 pmol/mouse produced a strong antinociceptive 
      effect as evaluated by hot plate method in mice. The effect was dose-dependent 
      and lasted for more than 120 min. The opioid receptor antagonist naloxone did not 
      antagonize, and the cyclooxygenase inhibitors indomethacin and diclofenac 
      slightly inhibited the ET-1 effect. The calcium overload blocker cinnarizine 
      antagonized the antinociceptive effect of ET-1, suggesting that the ET-1 effect 
      might be Ca(2+)-mediated.
FAU - Nikolov, R
AU  - Nikolov R
AD  - Chemical Pharmaceutical Research Institute, Bulgarian Academy of Sciences, Sofia.
FAU - Maslarova, J
AU  - Maslarova J
FAU - Semkova, I
AU  - Semkova I
FAU - Moyanova, S
AU  - Moyanova S
LA  - eng
PT  - Journal Article
PL  - Spain
TA  - Methods Find Exp Clin Pharmacol
JT  - Methods and findings in experimental and clinical pharmacology
JID - 7909595
RN  - 0 (Endothelins)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - *Analgesia
MH  - Animals
MH  - Calcium/*physiology
MH  - Dose-Response Relationship, Drug
MH  - Endothelins/administration & dosage/*pharmacology
MH  - Hot Temperature
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
EDAT- 1992/04/01 00:00
MHDA- 1992/04/01 00:01
CRDT- 1992/04/01 00:00
PHST- 1992/04/01 00:00 [pubmed]
PHST- 1992/04/01 00:01 [medline]
PHST- 1992/04/01 00:00 [entrez]
PST - ppublish
SO  - Methods Find Exp Clin Pharmacol. 1992 Apr;14(3):229-33.