PMID- 16255843
OWN - NLM
STAT- MEDLINE
DCOM- 20060420
LR  - 20131121
IS  - 0021-521X (Print)
IS  - 0021-521X (Linking)
VI  - 55
IP  - 4
DP  - 2005 Aug
TI  - Effect of hypothyroidism on intestinal zinc absorption and renal zinc disposal in 
      five-sixths nephrectomized rats.
PG  - 211-9
AB  - Both hypothyroid (Hypo) and hypozincemia are commonly observed in patients and 
      animals with chronic renal failure (CRF). In CRF whether the hypothyroid plays a 
      role in the pathogenesis of hypozincemia is unclear. This study is designed to 
      investigate the effects of hypothyroid on intestinal zinc absorption and urinary 
      zinc excretion in 5/6 nephrectomized (Nx) rats, because plasma zinc balance is 
      attained through a controlled rate of intestinal uptake as well as renal 
      reabsorption. Intestinal zinc absorption was carried out in jejunum and ileum 
      segments by an in vivo perfusion technique and the renal zinc disposal was 
      evaluated by a conventional method using a standard formula to calculate the zinc 
      tubular reabsorption and the excretion of urinary zinc in 5/6 Nx rats with 
      hypothyroidism. The Hypo-NxT rats showed a significant decrease in the rate of 
      intestinal zinc absorption and in the response of plasma zinc levels during 
      intestinal zinc perfusion compared with Eu-NxT rats. They also had significantly 
      lower levels of mucosal zinc and MT as well as lower content of liver zinc than 
      Eu-NxT rats after intestinal zinc perfusion for 80 min. Hypo-NxT rats showed low 
      plasma zinc levels, but had a similar output of pancreaticobiliary zinc and 
      excretion of 24-h urine zinc compared with the Eu-NxT rats. When 2% alcohol 
      intestinal perfusion was used to produce water diuresis, the Hypo-NxT rats 
      presented a higher excretion of urinary zinc than the Eu-NxT rats did, especially 
      during 2% alcohol intestinal zinc perfusion. In the Hypo-NxT rats, the lower 
      plasma zinc levels may thus result from the hypothyroid because it reduces 
      intestinal zinc absorption. Increasing the urine flow rate may aggravate the 
      reduction of plasma zinc level in Hypo-NxT rats because of the increased 
      excretion of urinary zinc.
FAU - Chen, Shu-Ming
AU  - Chen SM
AD  - Department of Medical Research and Education, Nephrology Laboratory, Taipei 
      Veterans General Hospital, Taipei, Taiwan 11217, ROC. smchen@vghtpe.gov.tw
FAU - Kuo, Cheng-Deng
AU  - Kuo CD
FAU - Ho, Low-Tone
AU  - Ho LT
FAU - Liao, Jyh-Fei
AU  - Liao JF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051029
PL  - Japan
TA  - Jpn J Physiol
JT  - The Japanese journal of physiology
JID - 2985184R
RN  - 721M9407IY (Propylthiouracil)
RN  - 9038-94-2 (Metallothionein)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Animals
MH  - Hypothyroidism/chemically induced/*physiopathology
MH  - Intestinal Absorption/*physiology
MH  - Kidney/*physiology
MH  - Kidney Failure, Chronic/*physiopathology
MH  - Male
MH  - Metallothionein/metabolism
MH  - Nephrectomy
MH  - Propylthiouracil
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Zinc/blood/*pharmacokinetics/urine
EDAT- 2005/11/01 09:00
MHDA- 2006/04/21 09:00
CRDT- 2005/11/01 09:00
PHST- 2005/07/27 00:00 [received]
PHST- 2005/10/27 00:00 [accepted]
PHST- 2005/11/01 09:00 [pubmed]
PHST- 2006/04/21 09:00 [medline]
PHST- 2005/11/01 09:00 [entrez]
AID - jjphysiol/R2124 [pii]
AID - 10.2170/jjphysiol.R2124 [doi]
PST - ppublish
SO  - Jpn J Physiol. 2005 Aug;55(4):211-9. doi: 10.2170/jjphysiol.R2124. Epub 2005 Oct 
      29.