PMID- 16257112
OWN - NLM
STAT- MEDLINE
DCOM- 20070212
LR  - 20091014
IS  - 0303-8467 (Print)
IS  - 0303-8467 (Linking)
VI  - 108
IP  - 8
DP  - 2006 Dec
TI  - Progressive multifocal leukoencephalopathy in an HTLV-I carrier.
PG  - 768-71
AB  - This report describes a previously 28-year-old healthy woman, identified as an 
      asymptomatic human T-lymphotropic virus type I (HTLV-I) carrier, who developed 
      both progressive multifocal leukoencephalopathy (PML) and Pneumocystis jiroveci 
      pneumonia. For diagnostic confirmation of PML, stereotactic brain biopsy 
      demonstrated multiple demyelinating lesions with the presence of JC viral 
      antigen. Intramuscular alpha-interferon therapy for 2 weeks brought considerable 
      neurologic improvement. Three years later, the patient developed lymphoma-type of 
      adult T-cell leukemia, suggesting that HTLV-I carrier might be one of the 
      underlying diseases of PML.
FAU - Kimura, Akiko
AU  - Kimura A
AD  - Division of Neurology and Neuromuscular Disorders, Department of Brain and Nerve 
      Science, Oita University Faculty of Medicine, Hasama-machi, Oita 879-5593, Japan.
FAU - Ueyama, Hidetsugu
AU  - Ueyama H
FAU - Kimura, Noriyuki
AU  - Kimura N
FAU - Fujimoto, Shin
AU  - Fujimoto S
FAU - Kumamoto, Toshihide
AU  - Kumamoto T
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20051027
PL  - Netherlands
TA  - Clin Neurol Neurosurg
JT  - Clinical neurology and neurosurgery
JID - 7502039
RN  - 0 (HTLV-I Antigens)
RN  - 0 (Interferon-alpha)
SB  - IM
MH  - Adult
MH  - Biopsy
MH  - Brain/pathology
MH  - Carrier State/*diagnosis/drug therapy/pathology
MH  - Diagnosis, Differential
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Frontal Lobe/pathology/virology
MH  - HTLV-I Antigens/blood
MH  - HTLV-I Infections/*diagnosis/drug therapy/pathology
MH  - Humans
MH  - Injections, Intramuscular
MH  - Interferon-alpha/administration & dosage
MH  - Leukemia-Lymphoma, Adult T-Cell/diagnosis/pathology
MH  - Leukoencephalopathy, Progressive Multifocal/*diagnosis/drug therapy/pathology
MH  - Lymph Nodes/pathology
MH  - Magnetic Resonance Imaging
MH  - Oligodendroglia/pathology/virology
MH  - Opportunistic Infections/*diagnosis/drug therapy/pathology
MH  - Tomography, X-Ray Computed
EDAT- 2005/11/01 09:00
MHDA- 2007/02/13 09:00
CRDT- 2005/11/01 09:00
PHST- 2005/01/08 00:00 [received]
PHST- 2005/08/18 00:00 [revised]
PHST- 2005/09/04 00:00 [accepted]
PHST- 2005/11/01 09:00 [pubmed]
PHST- 2007/02/13 09:00 [medline]
PHST- 2005/11/01 09:00 [entrez]
AID - S0303-8467(05)00154-X [pii]
AID - 10.1016/j.clineuro.2005.09.006 [doi]
PST - ppublish
SO  - Clin Neurol Neurosurg. 2006 Dec;108(8):768-71. doi: 
      10.1016/j.clineuro.2005.09.006. Epub 2005 Oct 27.