PMID- 16260351
OWN - NLM
STAT- MEDLINE
DCOM- 20060203
LR  - 20061115
IS  - 1056-8727 (Print)
IS  - 1056-8727 (Linking)
VI  - 19
IP  - 6
DP  - 2005 Nov-Dec
TI  - Early treadmill exercise decreases intrastriatal hemorrhage-induced neuronal cell 
      death and increases cell proliferation in the dentate gyrus of 
      streptozotocin-induced hyperglycemic rats.
PG  - 339-46
AB  - Intracerebral hemorrhage (ICH) is a severe complication in diabetic patients. 
      Currently, physical exercise is recommended as a behavioral intervention to 
      promote functional recovery in brain diseases, including ICH. Recently, 
      hyperglycemia is known to aggravate brain injury in experimental ICH. Here, we 
      examined the effect of treadmill exercise on the intrastriatal hemorrhage-induced 
      neuronal cell death and cell proliferation in the dentate gyrus of hyperglycemic 
      rats. Hyperglycemia was induced by the intraperitoneal injection of 50 mg/kg 
      streptozotocin (STZ). Intrastriatal hemorrhage was induced by the infusion of 0.2 
      U collagenase into the striatum using stereotaxic instrument. Rats in the 
      exercise groups were forced to run on a treadmill for 30 min daily for 10 days. 
      Apoptosis was assessed by the terminal deoxynucleotidyl transferase-mediated dUTP 
      nick end labeling (TUNEL) assay. Cell proliferation was assessed by the 
      5-bromo-2'-deoxyuridine (BrdU) immunohistochemistry. Our data showed that in rats 
      started treadmill exercise 24 h after ICH induction, the size of lesion induced 
      by hemorrhage and the number of apoptotic cells were decreased significantly. The 
      number of proliferating cells in the dentate gyrus was significantly decreased in 
      hyperglycemic rats. Treadmill exercise markedly enhanced cell proliferation in 
      the dentate gyrus of hyperglycemic rats. The data suggest that treadmill exercise 
      may provide therapeutic value to ICH patients with hyperglycemia by suppressing 
      neuronal apoptosis and increasing cell proliferation.
FAU - Lee, Hee-Hyuk
AU  - Lee HH
AD  - Department of Physiology, College of Medicine, Kyung Hee University, #1 
      Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea.
FAU - Shin, Mal-Soon
AU  - Shin MS
FAU - Kim, Young-Sick
AU  - Kim YS
FAU - Yang, Hye-Young
AU  - Yang HY
FAU - Chang, Hyun-Kyung
AU  - Chang HK
FAU - Lee, Taeck-Hyun
AU  - Lee TH
FAU - Kim, Chang-Ju
AU  - Kim CJ
FAU - Cho, Sonhae
AU  - Cho S
FAU - Hong, Seon-Pyo
AU  - Hong SP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Animals
MH  - Antibiotics, Antineoplastic/toxicity
MH  - *Apoptosis
MH  - Blood Glucose/metabolism
MH  - Cell Proliferation
MH  - Cerebral Hemorrhage/metabolism/*pathology
MH  - Corpus Striatum/*pathology
MH  - Dentate Gyrus/*pathology
MH  - Diabetes Mellitus, Experimental
MH  - Hyperglycemia/chemically induced/*pathology
MH  - In Situ Nick-End Labeling
MH  - Injections, Intraperitoneal
MH  - Male
MH  - Neurons/*pathology
MH  - *Physical Conditioning, Animal
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2005/11/02 09:00
MHDA- 2006/02/04 09:00
CRDT- 2005/11/02 09:00
PHST- 2004/05/17 00:00 [received]
PHST- 2005/03/18 00:00 [revised]
PHST- 2005/03/24 00:00 [accepted]
PHST- 2005/11/02 09:00 [pubmed]
PHST- 2006/02/04 09:00 [medline]
PHST- 2005/11/02 09:00 [entrez]
AID - S1056-8727(05)00031-0 [pii]
AID - 10.1016/j.jdiacomp.2005.03.006 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2005 Nov-Dec;19(6):339-46. doi: 
      10.1016/j.jdiacomp.2005.03.006.