PMID- 16260972
OWN - NLM
STAT- MEDLINE
DCOM- 20060117
LR  - 20190902
IS  - 0195-9131 (Print)
IS  - 0195-9131 (Linking)
VI  - 37
IP  - 10
DP  - 2005 Oct
TI  - Metabolic responses to exercise after carbohydrate loads in healthy men and 
      women.
PG  - 1721-7
AB  - PURPOSE: This study aimed to investigate gender differences in i) pancreatic 
      insulin secretory (beta-cell sensitivity) and whole body insulin sensitivity 
      responses to an intravenous carbohydrate (CHO) load, and (ii) metabolic responses 
      to exercise after both intravenous and oral CHO loads. METHODS: Seven untrained 
      healthy men and seven age-, body mass-, and VO2max-matched women performed two 
      trials. In one trial they cycled for 60 min at 50% VO2max, starting 60 min after 
      ingestion of a carbohydrate-rich meal (ME trial). In the other trial, subjects 
      were infused with 20% dextrose solution to maintain blood glucose concentration 
      at approximately 8 mmol x L(-1) for 60 min (INF trial), then the infusion rate 
      was maintained constant during the following 60 min while exercising at 50% 
      VO2max. RESULTS: There was no gender effect on beta-cell sensitivity (serum 
      insulin: 161 +/- 37 and 159 +/- 28 pmol x L(-1) for men and women, respectively) 
      and whole body insulin sensitivity (155 +/- 24 and 135 +/- 29 mg x KgFFM(-1) x 
      min(-1) per pmol x L(-1) x 100 for men and women, respectively). This may explain 
      the similarity in glycemic, substrate oxidation and other metabolic responses to 
      exercise after both intravenous and oral CHO loads in men and women. CONCLUSION: 
      These results suggest that moderate exercise performed in the postprandial state 
      presents a similar challenge to the ability of healthy, untrained men and women 
      to perform exercise without a substantial decline in plasma glucose concentration 
      below fasting values.
FAU - Leelayuwat, Naruemon
AU  - Leelayuwat N
AD  - Centre for Integrated Biology and Medicine, Institute of Clinical Research, 
      University of Nottingham Medical School, Nottingham, United Kingdom.
FAU - Tsintzas, Kostas
AU  - Tsintzas K
FAU - Patel, Kishor
AU  - Patel K
FAU - Macdonald, Ian A
AU  - Macdonald IA
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Breath Tests
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Female
MH  - Glucose Clamp Technique
MH  - Humans
MH  - Insulin/blood
MH  - Male
MH  - Oxygen Consumption
MH  - Postprandial Period
MH  - Sex Factors
EDAT- 2005/11/02 09:00
MHDA- 2006/01/18 09:00
CRDT- 2005/11/02 09:00
PHST- 2005/11/02 09:00 [pubmed]
PHST- 2006/01/18 09:00 [medline]
PHST- 2005/11/02 09:00 [entrez]
AID - 00005768-200510000-00011 [pii]
AID - 10.1249/01.mss.0000181401.30591.4f [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 2005 Oct;37(10):1721-7. doi: 
      10.1249/01.mss.0000181401.30591.4f.