PMID- 16261786
OWN - NLM
STAT- MEDLINE
DCOM- 20060120
LR  - 20170511
IS  - 0001-5385 (Print)
IS  - 0001-5385 (Linking)
VI  - 60
IP  - 5
DP  - 2005 Oct
TI  - Prognostic value of B-type natriuretic peptide levels on admission in patients 
      with acute ST elevation myocardial infarction.
PG  - 537-42
AB  - OBJECTIVE: To assess the relation between B-type natriuretic peptide (BNP) levels 
      on admission in ST elevation myocardial infarction (STEMI) and short-term, 
      all-cause mortality. METHODS AND RESULTS: Blood samples for BNP determination 
      were obtained on admission in 88 patients (mean age 60.6 +/- 10.7 years old) with 
      STEMI. In a 15-minute period, BNP was measured by using simple bedside test for 
      rapid quantification of BNP. Thirty days follow-up was performed. During the 
      period of follow-up 12 (13.6%) patients died. Mean BNP was 228.74 +/- 269.98 
      pg/ml. The lowest value was 5 pg/ml, the highest value 1300 pg/ml due to 
      limitations of the method. The baseline level of BNP was higher among patients 
      who died than among those who were alive at 30 days (mean, 545.6 vs. 178.7 pg/ml; 
      P = 0.001). Mortality increased among patients in increasing quartiles (p = 
      0.009). The unadjusted odds ratio for 30-day risk of death in the fourth quartile 
      was 5.6 (95 percent confidence interval, 1.6 to 20.5; P < 0.001). When BNP was 
      added to a multivariate Cox regression model including clinical and 
      electrocardiographic variables, BNP levels were independently associated with the 
      prognosis. CONCLUSIONS: BNP levels obtained on admission are a powerful, 
      independent indicator of short-term mortality in patients with STEMI. Rapid tests 
      for BNP assay seem to be a new tool in risk stratification of patients with 
      STEMI.
FAU - Grabowski, Marcin
AU  - Grabowski M
AD  - 1st Department of Cardiology, Medical University of Warsaw, Central University 
      Hospital, Warsaw, Poland. marcin.grabowski@amwaw.edu.pl
FAU - Filipiak, Krzysztof J
AU  - Filipiak KJ
FAU - Karpinski, Grzegorz
AU  - Karpinski G
FAU - Wretowski, Dominik
AU  - Wretowski D
FAU - Rdzanek, Adam
AU  - Rdzanek A
FAU - Rudzki, Dariusz
AU  - Rudzki D
FAU - Glowczynska, Renata
AU  - Glowczynska R
FAU - Rudowski, Robert
AU  - Rudowski R
FAU - Opolski, Grzegorz
AU  - Opolski G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Acta Cardiol
JT  - Acta cardiologica
JID - 0370570
RN  - 0 (Biomarkers)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angioplasty, Balloon, Coronary
MH  - Biomarkers/blood
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Conduction System/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Myocardial Infarction/*blood/*diagnosis/mortality/physiopathology/therapy
MH  - Natriuretic Peptide, Brain/*blood
MH  - Odds Ratio
MH  - *Patient Admission
MH  - Prognosis
MH  - Sensitivity and Specificity
MH  - Survival Analysis
MH  - Treatment Outcome
EDAT- 2005/11/03 09:00
MHDA- 2006/01/21 09:00
CRDT- 2005/11/03 09:00
PHST- 2005/11/03 09:00 [pubmed]
PHST- 2006/01/21 09:00 [medline]
PHST- 2005/11/03 09:00 [entrez]
AID - 10.2143/AC.60.5.2004976 [doi]
PST - ppublish
SO  - Acta Cardiol. 2005 Oct;60(5):537-42. doi: 10.2143/AC.60.5.2004976.