PMID- 16261886
OWN - NLM
STAT- MEDLINE
DCOM- 20061222
LR  - 20221207
IS  - 1001-9294 (Print)
IS  - 1001-9294 (Linking)
VI  - 20
IP  - 3
DP  - 2005 Sep
TI  - Association between pemphigus vulgaris and human leukocyte antigen in Han nation 
      of northeast China.
PG  - 166-70
AB  - OBJECTIVE: To investigate the relationship between pemphigus vulgaris (PV) and 
      human leukocyte antigen (HLA) in Han nation of northeast China. METHODS: Standard 
      microcytotoxicity test and polymerase chain reaction-sequence specific primers 
      method were used to detect the HLA class I antigens and HLA-DRB1 and DQB1 alleles 
      in 27 patients with PV and results were compared with control group. RESULTS: 
      Gene and phenotype frequencies of HLA-A3, A26(10), B60(40), and B13 (27.99%, 48%; 
      16.11%, 30%; 23.02%, 41%; 16.11%, 30%, respectively) increased significantly in 
      PV group compared with control (1.01%, 2%; 0.5%, 1%; 4.61%, 9%; 5.13%, 10%, 
      respectively). After P value correction, the difference of A3, A26 (10), and B60 
      (40) between the two groups was still significant. The gene frequencies of 
      HLA-DRB1*140x (1401, 1404, 1405, 1407, 1408), DRB1*120x, and DQB1*0503 alleles in 
      PV group (42.26%, 25.46%, and 23.02%) were significantly higher than control 
      group (5.09%, 7.74%, and 1.89%). After P value correction, the difference was 
      still significant between the two groups. CONCLUSION: PV significantly relates 
      with HLA in PV patients of Han nation of northeast China.
FAU - Geng, Long
AU  - Geng L
AD  - Department of Dermatology, First Affiliated Hospital, China Medical University, 
      Shenyang 110001. gength@yahoo.com.cn
FAU - Wang, Yan
AU  - Wang Y
FAU - Zhai, Ning
AU  - Zhai N
FAU - Lu, Ya-Ni
AU  - Lu YN
FAU - Song, Fang-Ji
AU  - Song FJ
FAU - Chen, Hong-Duo
AU  - Chen HD
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med Sci J
JT  - Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
JID - 9112559
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A3 Antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B60 antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/ethnology
MH  - China/ethnology
MH  - Female
MH  - Gene Frequency
MH  - HLA-A Antigens/*genetics
MH  - HLA-A3 Antigen/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pemphigus/*genetics
MH  - Phenotype
EDAT- 2005/11/03 09:00
MHDA- 2006/12/23 09:00
CRDT- 2005/11/03 09:00
PHST- 2005/11/03 09:00 [pubmed]
PHST- 2006/12/23 09:00 [medline]
PHST- 2005/11/03 09:00 [entrez]
PST - ppublish
SO  - Chin Med Sci J. 2005 Sep;20(3):166-70.