PMID- 16261898
OWN - NLM
STAT- MEDLINE
DCOM- 20061222
LR  - 20181201
IS  - 1001-9294 (Print)
IS  - 1001-9294 (Linking)
VI  - 20
IP  - 3
DP  - 2005 Sep
TI  - Expression and significance of Survivin mRNA in lung cancer tissue microarray 
      detected by FISH.
PG  - 214-6
AB  - OBJECTIVE: To investigate the expression of Survivin mRNA in lung cancer tissue 
      microarray (TMA) by fluorescence in situ hybridization (FISH) method, and 
      determine the role and significance of it in lung cancer genesis and progress. 
      METHODS: The expression of Survivin mRNA was detected by FISH method and TMA 
      technology. Fifty-four cases of lung cancer and 10 cases of normal lung tissue 
      were examined. RESULTS: Survivin mRNA was expressed in 66.7% (36/54) of lung 
      cancer; the positive ratio of lung cancer was significantly higher than that of 
      normal lung tissue (0/10; chi2 = 15.238, P < 0.05). The positive ratio of 
      Survivin mRNA was significantly higher in poor differentiated cancer (20/24, 
      83.3%) than moderate and well differentiated cancer (16/30, 53.3%; chi2 = 5.40, P 
      < 0.05). The positive ratio of Survivin mRNA was significantly higher in group 
      with lymph node metastasis (27/32, 84.4%) than without lymph node metastasis 
      (9/22, 40.9%; chi2 = 11.084, P < 0.05). The positive ratio of Survivin mRNA was 
      significantly higher in stage III-IV(12/13, 92.3%) than stage I - II (24/41, 
      58.5%; chi2 = 5.066, P < 0.05). CONCLUSION: Survivin mRNA highly expresses in 
      lung cancer, which is related to the progress and malignant behavior. Survivin 
      may play a promoting role in lung cancer genesis and progress and provide a basis 
      for estimating prognosis and treatment.
FAU - Wang, Xin-Yun
AU  - Wang XY
AD  - Department of Pathology, Tianjin Medical University, Tianjin 300070. 
      saintpilu@yahoo.com.cn
FAU - Yao, Zhi
AU  - Yao Z
FAU - Li, Yan
AU  - Li Y
FAU - Liu, Ting
AU  - Liu T
FAU - Zheng, Hai-Yan
AU  - Zheng HY
FAU - Zhu, Cong-Zhong
AU  - Zhu CZ
FAU - Sun, Cui-Yun
AU  - Sun CY
FAU - Wang, Ai-Xiang
AU  - Wang AX
FAU - Zhao, Min
AU  - Zhao M
FAU - Wu, Xing-Ye
AU  - Wu XY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med Sci J
JT  - Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
JID - 9112559
RN  - 0 (BIRC5 protein, human)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Survivin)
SB  - IM
MH  - Adenocarcinoma/metabolism/secondary
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/metabolism/secondary
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Inhibitor of Apoptosis Proteins
MH  - Lung Neoplasms/*metabolism/pathology
MH  - Lymph Nodes/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Microtubule-Associated Proteins/*biosynthesis/genetics
MH  - Middle Aged
MH  - Neoplasm Proteins/*biosynthesis/genetics
MH  - Neoplasm Staging
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Survivin
MH  - Tissue Array Analysis
EDAT- 2005/11/03 09:00
MHDA- 2006/12/23 09:00
CRDT- 2005/11/03 09:00
PHST- 2005/11/03 09:00 [pubmed]
PHST- 2006/12/23 09:00 [medline]
PHST- 2005/11/03 09:00 [entrez]
PST - ppublish
SO  - Chin Med Sci J. 2005 Sep;20(3):214-6.