PMID- 16263378
OWN - NLM
STAT- MEDLINE
DCOM- 20060124
LR  - 20151119
IS  - 0045-6535 (Print)
IS  - 0045-6535 (Linking)
VI  - 61
IP  - 8
DP  - 2005 Dec
TI  - Screening of POP pollution by AChE and EROD activities in Zebra mussels from the 
      Italian Great Lakes.
PG  - 1074-82
AB  - The increase of ethoxyresorufin dealkylation (EROD) and the inhibition of 
      acetylcholinesterase (AChE) as biomarkers have been commonly used in vertebrates 
      for the persistent organic pollutants (POPs) biomonitoring of aquatic 
      environments, but very few studies have been performed for invertebrates. 
      Previous researches demonstrated the interference due to some chemicals on EROD 
      and AChE activities of the freshwater bivalve Zebra mussel (Dreissena polymorpha) 
      in laboratory and field studies, showing its possible use for the screening of 
      POP effects. We investigated the contamination of the Italian sub-alpine great 
      lakes (Maggiore, Lugano, Como, Iseo, Garda) by the biomarker approach on Zebra 
      mussel specimens collected at 17 sampling sites with different morphometric 
      characteristics and anthropization levels. Results showed a homogeneous 
      contamination of AChE inhibitors in Lake Garda, Maggiore, Como and Iseo with 
      values ranging from 0.5 to 3 nmol/min/mg proteins and with an average inhibition 
      of about 66% to controls. The planar compounds pollution, able to activate the 
      EROD activity, seems higher in some sampling stations of Lake Garda, Como and 
      Iseo (2-4 pmol/min/mg proteins) than that measured in Lake Lugano (1.5-3 
      pmol/min/mg proteins). On the contrary, the enzyme activity in Lake Maggiore 
      showed an interesting opposite effect of AhR-binding compounds and trace metals. 
      Finally, the possible use of Zebra mussel specimens maintained at laboratory 
      conditions as controls against the selection of the less polluted sampling site 
      is discussed.
FAU - Binelli, A
AU  - Binelli A
AD  - Department of Biology, University of Milan, Via Celoria 26, 20133 Milan, Italy. 
      andrea.binelli@unimi.it
FAU - Ricciardi, Francesco
AU  - Ricciardi F
FAU - Riva, Consuelo
AU  - Riva C
FAU - Provini, Alfredo
AU  - Provini A
LA  - eng
PT  - Journal Article
DEP - 20050425
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Biomarkers)
RN  - 0 (Cholinesterase Inhibitors)
RN  - 0 (Insecticides)
RN  - 0 (Water Pollutants, Chemical)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - 5598-15-2 (O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate)
RN  - CIW5S16655 (DDT)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
RN  - JCS58I644W (Chlorpyrifos)
SB  - IM
MH  - Acetylcholinesterase/*metabolism
MH  - Animals
MH  - Biomarkers
MH  - Chlorpyrifos/analogs & derivatives/analysis/metabolism/toxicity
MH  - Cholinesterase Inhibitors/analysis/metabolism/toxicity
MH  - Cytochrome P-450 CYP1A1/*metabolism
MH  - DDT/analysis/metabolism/toxicity
MH  - Dreissena/*enzymology/metabolism
MH  - Environmental Monitoring
MH  - Fresh Water
MH  - Hexachlorobenzene/analysis/metabolism/toxicity
MH  - Insecticides/analysis/metabolism/toxicity
MH  - Italy
MH  - Polychlorinated Biphenyls/analysis/metabolism/toxicity
MH  - Temperature
MH  - Water Pollutants, Chemical/analysis/metabolism/*toxicity
EDAT- 2005/11/03 09:00
MHDA- 2006/01/25 09:00
CRDT- 2005/11/03 09:00
PHST- 2004/10/07 00:00 [received]
PHST- 2005/03/08 00:00 [revised]
PHST- 2005/03/17 00:00 [accepted]
PHST- 2005/11/03 09:00 [pubmed]
PHST- 2006/01/25 09:00 [medline]
PHST- 2005/11/03 09:00 [entrez]
AID - S0045-6535(05)00458-3 [pii]
AID - 10.1016/j.chemosphere.2005.03.047 [doi]
PST - ppublish
SO  - Chemosphere. 2005 Dec;61(8):1074-82. doi: 10.1016/j.chemosphere.2005.03.047. Epub 
      2005 Apr 25.