PMID- 16263823
OWN - NLM
STAT- MEDLINE
DCOM- 20060131
LR  - 20220311
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 91
IP  - 1
DP  - 2006 Jan
TI  - Helicobacter pylori infection and autoimmune thyroid disease in young patients: 
      the disadvantage of carrying the human leukocyte antigen-DRB1*0301 allele.
PG  - 176-9
AB  - CONTEXT AND OBJECTIVE: Pathogenesis of autoimmune thyroid disease (ATD) is 
      multifactorial. Helicobacter pylori (Hp) infection has been proposed to be 
      involved in nongastrointestinal conditions and reported more frequently in ATD 
      adult patients. We evaluated the prevalence of Hp antibodies in young ATD 
      patients and investigated the possibility that a susceptible immunogenetic 
      profile could influence the development of ATD in subjects with Hp infection. 
      SUBJECTS AND METHODS: We retrospectively studied 90 children with ATD (median age 
      11.2 yr), 70 age- and sex-matched healthy subjects as controls, and 65 patients 
      with Turner syndrome (median age 18.8 yr). Antibodies to Hp were determined at 
      diagnosis in ATD patients and, in Turner patients, at the last control in cases 
      without ATD and before the appearance of thyroid autoantibodies in the others. 
      Serological and molecular human leukocyte antigen (HLA) typing for classes I and 
      II polymorphisms was performed. RESULTS: Prevalence of positive Hp serology 
      resulted significantly higher in ATD patients than controls (P = 0.032). No 
      association was found between individual HLA alleles and Hp serology. HLA-A1, B8, 
      and DRB1*0301 were found significantly associated with ATD. A significant 
      interaction between HLA-DRB1*0301 and Hp infection was present in ATD patients 
      and not controls (P = 0.007), suggesting that the copresence of these two factors 
      might favor ATD development. A similar phenomenon was observed in Turner syndrome 
      patients (P = 0.02; cumulative Mantel test, P = 0.0001). CONCLUSIONS: Another 
      target of Hp-elicited immune inflammatory response might be the thyroid gland in 
      subjects with a peculiar immunogenetic profile so that ATD may be a consequence. 
      Our findings suggest the opportunity of eradicating Hp infection in children with 
      ATD and/or susceptible HLA alleles.
FAU - Larizza, Daniela
AU  - Larizza D
AD  - Department of Pediatric Sciences, University of Pavia and Istituto di Ricovero e 
      Cura a Carattere Scientifico Policlinico San Matteo, 27100 Pavia, Italy. 
      d.larizza@smatteo.pv.it
FAU - Calcaterra, Valeria
AU  - Calcaterra V
FAU - Martinetti, Miryam
AU  - Martinetti M
FAU - Negrini, Riccardo
AU  - Negrini R
FAU - De Silvestri, Annalisa
AU  - De Silvestri A
FAU - Cisternino, Mariangela
AU  - Cisternino M
FAU - Iannone, A M
AU  - Iannone AM
FAU - Solcia, Enrico
AU  - Solcia E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051101
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Antibodies, Bacterial/analysis
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gene Frequency
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Helicobacter Infections/*complications/epidemiology/*genetics
MH  - *Helicobacter pylori
MH  - Histocompatibility Testing
MH  - Humans
MH  - Infant
MH  - Male
MH  - Polymorphism, Genetic
MH  - Retrospective Studies
MH  - Thyroiditis, Autoimmune/*complications/epidemiology/*genetics
MH  - Turner Syndrome/genetics/physiopathology
EDAT- 2005/11/03 09:00
MHDA- 2006/02/01 09:00
CRDT- 2005/11/03 09:00
PHST- 2005/11/03 09:00 [pubmed]
PHST- 2006/02/01 09:00 [medline]
PHST- 2005/11/03 09:00 [entrez]
AID - jc.2005-1272 [pii]
AID - 10.1210/jc.2005-1272 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2006 Jan;91(1):176-9. doi: 10.1210/jc.2005-1272. Epub 
      2005 Nov 1.