PMID- 16266386
OWN - NLM
STAT- MEDLINE
DCOM- 20060126
LR  - 20211203
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 60
IP  - 12
DP  - 2005 Dec
TI  - New cohorts of naive T cells exacerbate ongoing allergy but can be suppressed by 
      regulatory T cells.
PG  - 1530-6
AB  - Although as pretreatment oral tolerance is a potent means to achieve systemic 
      suppression, its application in ongoing disease is controversial. Here we propose 
      that availability of naive T cells may critically determine whether immunological 
      tolerance is achieved during ongoing antigenic reactivity. Infusion of naive 
      antigen-specific T cells into mice directly prior to eliciting a secondary Th2 
      response induces these naive cells to actively engage in the antigenic response 
      despite presence of established memory. Naive antigen-specific T-cells divided 
      faster, produced more interleukin (IL)-2, IL-4 and IL-5 and enhanced 
      immunoglobulin E (IgE) release during a secondary Th2 response, compared with 
      naive T cells that were infused prior to a primary response. Despite such 
      contribution by new cohorts of naive T cells co-infusion of mucosal Tr together 
      with naive T cells could suppress enhanced IgE release during a secondary Th2 
      response. We conclude that naive T cells contribute to a secondary Th2 response 
      and although they can still be suppressed in the presence of sufficient numbers 
      of mucosal Tr, they may interfere with potential therapeutic application of 
      mucosal tolerance.
FAU - Hauet-Broere, F
AU  - Hauet-Broere F
AD  - Department of Molecular Cell Biology and Immunology, VU Medical Center, PO Box 
      7057, Amsterdam, the Netherlands.
FAU - Unger, W W J
AU  - Unger WW
FAU - van Berkel, L A
AU  - van Berkel LA
FAU - Garssen, J
AU  - Garssen J
FAU - Hoijer, M A
AU  - Hoijer MA
FAU - Kraal, G
AU  - Kraal G
FAU - Samsom, J N
AU  - Samsom JN
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - Hypersensitivity/*immunology/*physiopathology
MH  - Immune Tolerance
MH  - *Immunosuppression Therapy
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Transgenic
MH  - Mucous Membrane/immunology
MH  - Receptors, Antigen, T-Cell/genetics
MH  - T-Lymphocytes, Regulatory/*immunology
MH  - Th2 Cells/immunology
EDAT- 2005/11/04 09:00
MHDA- 2006/01/27 09:00
CRDT- 2005/11/04 09:00
PHST- 2005/11/04 09:00 [pubmed]
PHST- 2006/01/27 09:00 [medline]
PHST- 2005/11/04 09:00 [entrez]
AID - ALL925 [pii]
AID - 10.1111/j.1398-9995.2005.00925.x [doi]
PST - ppublish
SO  - Allergy. 2005 Dec;60(12):1530-6. doi: 10.1111/j.1398-9995.2005.00925.x.