PMID- 16267768
OWN - NLM
STAT- MEDLINE
DCOM- 20060119
LR  - 20131121
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 192
IP  - 11
DP  - 2005 Dec 1
TI  - Parasitological rebound effect and emergence of pyrimethamine resistance in 
      Plasmodium falciparum after single-dose sulfadoxine-pyrimethamine.
PG  - 1962-5
AB  - Intermittent preventive treatment for malaria in infants (IPTi) is a promising 
      malaria control strategy. However, mass preventive treatment for malaria 
      inherently bears the risk of increasing drug resistance. Here, the effect of 
      single-dose sulfadoxine-pyrimethamine (S-P) versus placebo on Plasmodium 
      falciparum infection rates was assessed in 63 selected infants who were 
      aparasitemic at enrollment. An increase in the proportion of infants with 
      isolates exhibiting drug resistance-associated mutations was detected 3 weeks 
      after drug application in the treatment group. S-P, in the setting of IPTi, 
      appears to cause a parasitological rebound effect in which there is selection of 
      drug-resistant parasites for a short period after drug clearance.
FAU - Marks, Florian
AU  - Marks F
AD  - Infection Epidemiology Group, Bernhard Nocht Institute for Tropical Medicine, 
      Hamburg, Germany.
FAU - von Kalckreuth, Vera
AU  - von Kalckreuth V
FAU - Kobbe, Robin
AU  - Kobbe R
FAU - Adjei, Samuel
AU  - Adjei S
FAU - Adjei, Ohene
AU  - Adjei O
FAU - Horstmann, Rolf D
AU  - Horstmann RD
FAU - Meyer, Christian G
AU  - Meyer CG
FAU - May, Jurgen
AU  - May J
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20051020
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antimalarials)
RN  - 0 (Drug Combinations)
RN  - 37338-39-9 (fanasil, pyrimethamine drug combination)
RN  - 88463U4SM5 (Sulfadoxine)
RN  - Z3614QOX8W (Pyrimethamine)
SB  - IM
EIN - J Infect Dis. 2006 May 1;193(9):1340
CIN - J Infect Dis. 2006 Jun 1;193(11):1609-10; author reply 1610-1. PMID: 16652293
MH  - Animals
MH  - Antimalarials/*administration & dosage/therapeutic use
MH  - Drug Combinations
MH  - Drug Resistance/genetics
MH  - Humans
MH  - Infant
MH  - Malaria, Falciparum/*drug therapy/parasitology
MH  - Plasmodium falciparum/*drug effects/genetics/isolation & purification
MH  - Pyrimethamine/administration & dosage/*pharmacology/therapeutic use
MH  - Sulfadoxine/*administration & dosage/therapeutic use
EDAT- 2005/11/04 09:00
MHDA- 2006/01/20 09:00
CRDT- 2005/11/04 09:00
PHST- 2005/04/26 00:00 [received]
PHST- 2005/06/22 00:00 [accepted]
PHST- 2005/11/04 09:00 [pubmed]
PHST- 2006/01/20 09:00 [medline]
PHST- 2005/11/04 09:00 [entrez]
AID - JID34844 [pii]
AID - 10.1086/497698 [doi]
PST - ppublish
SO  - J Infect Dis. 2005 Dec 1;192(11):1962-5. doi: 10.1086/497698. Epub 2005 Oct 20.