PMID- 16267776
OWN - NLM
STAT- MEDLINE
DCOM- 20060119
LR  - 20181113
IS  - 0022-1899 (Print)
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 192
IP  - 11
DP  - 2005 Dec 1
TI  - Association between human leukocyte antigen class II alleles and genotype of 
      Borrelia burgdorferi in patients with early lyme disease.
PG  - 2020-6
AB  - BACKGROUND: On the basis of a polymerase chain reaction-restriction 
      fragment-length polymorphism analysis of the 16S-23S ribosomal DNA intergenic 
      spacer, clinical isolates of Borrelia burgdorferi can be classified into 3 
      genotypes designated as RST1, RST2, and RST3. RST1 strains are the most 
      pathogenic, and RST3 strains are the least pathogenic. METHODS: Human leukocyte 
      antigen (HLA) class II alleles were determined for a group of culture-positive 
      patients with Lyme disease-associated erythema migrans and were evaluated for an 
      association with the genotype of the infecting B. burgdorferi strain. RESULTS: 
      The DRB1*0101 allele carriage rate was higher in patients infected with RST3 
      strains (9/25 [36.0%]) than in patients infected with RST1 strains (2/28 [7.1%]) 
      or RST2 strains (7/36 [19.4%]) (P=.010). The same relationship was found for 
      carriage of the DRB1*0101-DQB1*0501 haplotype (P=.018), because of tight linkage 
      disequilibrium. Similar associations could not be demonstrated for any of the 
      other DRB1 and DQB1 alleles or haplotypes that were assessed. CONCLUSION: The 
      DRB1*0101 allele and the DRB1*0101-DQB1*0501 haplotype may be relevant to the 
      development of infection with strains from the least invasive genotypes of B. 
      burgdorferi.
FAU - Wormser, Gary P
AU  - Wormser GP
AD  - Department of Medicine, Division of Infectious Diseases, New York Medical 
      College, Valhalla, NY 10595, USA. gary_wormser@nymc.edu
FAU - Kaslow, Richard
AU  - Kaslow R
FAU - Tang, Jianming
AU  - Tang J
FAU - Wade, Karen
AU  - Wade K
FAU - Liveris, Dionysios
AU  - Liveris D
FAU - Schwartz, Ira
AU  - Schwartz I
FAU - Klempner, Mark
AU  - Klempner M
LA  - eng
GR  - R01 AR041511-15/AR/NIAMS NIH HHS/United States
GR  - N01AI15441/AI/NIAID NIH HHS/United States
GR  - N01AI65308/AI/NIAID NIH HHS/United States
GR  - R01 AR041511/AR/NIAMS NIH HHS/United States
GR  - N01-AI65308/AI/NIAID NIH HHS/United States
GR  - R01-AR-41511/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20051028
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Borrelia burgdorferi/*classification/*genetics
MH  - Erythema Chronicum Migrans/*genetics/microbiology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Lyme Disease/*genetics/microbiology
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Restriction Fragment Length
PMC - PMC2776636
MID - NIHMS155827
COIS- Potential conflicts of interest: none reported.
EDAT- 2005/11/04 09:00
MHDA- 2006/01/20 09:00
PMCR- 2009/11/12
CRDT- 2005/11/04 09:00
PHST- 2005/02/10 00:00 [received]
PHST- 2005/06/30 00:00 [accepted]
PHST- 2005/11/04 09:00 [pubmed]
PHST- 2006/01/20 09:00 [medline]
PHST- 2005/11/04 09:00 [entrez]
PHST- 2009/11/12 00:00 [pmc-release]
AID - JID34418 [pii]
AID - 10.1086/497693 [doi]
PST - ppublish
SO  - J Infect Dis. 2005 Dec 1;192(11):2020-6. doi: 10.1086/497693. Epub 2005 Oct 28.