PMID- 16268263 OWN - NLM STAT- MEDLINE DCOM- 20060127 LR - 20181201 IS - 0011-4162 (Print) IS - 0011-4162 (Linking) VI - 76 IP - 3 DP - 2005 Sep TI - Subacute cutaneous lupus erythematosus associated with leflunomide. PG - 189-92 AB - A skin eruption consistent with subacute cutaneous lupus erythematosus (SCLE) occurred in a patient taking leflunomide for rheumatoid arthritis. The eruption resolved after discontinuation of the medication. Suppression of tumor necrosis factor (TNF)-effector mechanisms by leflunomide may have played a role in the pathogenesis of this disorder. FAU - Elias, Anthony R AU - Elias AR AD - Dermatology Clinic, US Army Medical Department Activity, Fort Drum, New York 13602, USA. anthony.elias@us.army.mil FAU - Tam, Christine C AU - Tam CC FAU - David-Bajar, Kathleen M AU - David-Bajar KM LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Cutis JT - Cutis JID - 0006440 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Isoxazoles) RN - G162GK9U4W (Leflunomide) SB - IM MH - Anti-Inflammatory Agents, Non-Steroidal/*adverse effects MH - Arthritis, Rheumatoid/drug therapy MH - Female MH - Humans MH - Isoxazoles/*adverse effects MH - Leflunomide MH - Lupus Erythematosus, Cutaneous/*chemically induced MH - Middle Aged EDAT- 2005/11/05 09:00 MHDA- 2006/01/28 09:00 CRDT- 2005/11/05 09:00 PHST- 2005/11/05 09:00 [pubmed] PHST- 2006/01/28 09:00 [medline] PHST- 2005/11/05 09:00 [entrez] PST - ppublish SO - Cutis. 2005 Sep;76(3):189-92.