PMID- 16269623
OWN - NLM
STAT- MEDLINE
DCOM- 20060404
LR  - 20210206
IS  - 0006-4971 (Print)
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 107
IP  - 4
DP  - 2006 Feb 15
TI  - HLAMatchmaker-driven analysis of responses to HLA-typed platelet transfusions in 
      alloimmunized thrombocytopenic patients.
PG  - 1680-7
AB  - This study describes a novel application of HLAMatchmaker to determine platelet 
      compatibility in 16 alloimmunized patients with aplastic anemia refractory to 
      random donor platelet transfusions. HLAMatchmaker is a software algorithm that 
      predicts HLA compatibility by identifying immunogenic epitopes represented by 
      amino acid triplets in antibody-accessible regions of human leukocyte antigen 
      (HLA) molecules and determines the number of triplet mismatches (TMMs) and highly 
      immunogenic triplet mismatches (HIMMs). Corrected count increments (CCIs) and 
      molecular HLA typing were available for 523 transfusions. Conventional 
      compatibility assessment based on cross-reactive group (CREG) determination was 
      not predictive of transfusion outcome. Low HIMMs and TMMs numbers were associated 
      with a higher likelihood of satisfactory (CCIs > or = 8) compared with 
      unsatisfactory (CCIs < 8) outcomes (median HIMMs = 4 vs 6, p2 value < .001; 
      median TMMs = 11 vs 13, p2 value < .001). Although receiver operator 
      characteristic curves revealed that HIMMs or TMMs number are not powerful 
      predictors of individual transfusion outcome, a threshold of at least 3 HIMMs or 
      at least 9 TMMs appeared to be associated with successful transfusions. 
      Triplet-matched transfusions were successful, regardless of CREG matching. Our 
      data validate HLAMatchmaker for platelet transfusions and demonstrate its 
      potential to refine and expand donor selection for HLA-alloimmunized patients.
FAU - Nambiar, Ashok
AU  - Nambiar A
AD  - Department of Transfusion Medicine, Bldg 10, 1C711, National Institutes of 
      Health, Bethesda, MD 20892, USA.
FAU - Duquesnoy, Rene J
AU  - Duquesnoy RJ
FAU - Adams, Sharon
AU  - Adams S
FAU - Zhao, Yingdong
AU  - Zhao Y
FAU - Oblitas, Jaime
AU  - Oblitas J
FAU - Leitman, Susan
AU  - Leitman S
FAU - Stroncek, David
AU  - Stroncek D
FAU - Marincola, Francesco
AU  - Marincola F
LA  - eng
GR  - R01-AI-55933/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20051103
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (Isoantigens)
SB  - IM
MH  - Cross Reactions
MH  - *HLA Antigens
MH  - HLA-A Antigens/immunology
MH  - HLA-B Antigens/immunology
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Isoantigens/immunology
MH  - Platelet Transfusion/adverse effects/*methods
MH  - Thrombocytopenia/blood/*immunology/*therapy
PMC - PMC1895402
EDAT- 2005/11/05 09:00
MHDA- 2006/04/06 09:00
PMCR- 2007/02/15
CRDT- 2005/11/05 09:00
PHST- 2005/11/05 09:00 [pubmed]
PHST- 2006/04/06 09:00 [medline]
PHST- 2005/11/05 09:00 [entrez]
PHST- 2007/02/15 00:00 [pmc-release]
AID - S0006-4971(20)66426-6 [pii]
AID - 1680 [pii]
AID - 10.1182/blood-2004-10-4080 [doi]
PST - ppublish
SO  - Blood. 2006 Feb 15;107(4):1680-7. doi: 10.1182/blood-2004-10-4080. Epub 2005 Nov 
      3.