PMID- 16270277
OWN - NLM
STAT- MEDLINE
DCOM- 20060216
LR  - 20161124
IS  - 1613-4125 (Print)
IS  - 1613-4125 (Linking)
VI  - 49
IP  - 11
DP  - 2005 Nov
TI  - 4-Hydroxynonenal and cholesterol oxidation products in atherosclerosis.
PG  - 1044-9
AB  - 4-Hydroxynonenal (HNE) is by far the most investigated aldehydic end-product of 
      oxidative breakdown of membrane n-6 polyunsaturated fatty acids. Its potential 
      involvement in the pathogenesis of atherosclerosis has been corroborated by its 
      consistent detection in both oxidized LDL and fibrotic plaque in humans. HNE has 
      been shown to activate both macrophage and smooth muscle cells, i.e. the two key 
      cell types in chronic inflammatory processes characterized by excessive 
      fibrogenesis. By signalling to the nucleus, the aldehyde may up-regulate in these 
      cells both expression and synthesis of monocyte chemotactic protein 1 (MCP-1) and 
      transforming growth factor beta1 (TGFbeta1). Oxysterols, namely 27 carbon atoms 
      oxidation products of cholesterol, are found in relatively high amount in LDL 
      from hypercholesterolemic individuals and are consistently detectable in foam 
      cells and necrotic core of human atherosclerotic lesion. As for HNE, the 
      challenge of cells of the macrophage lineage with a mixture of oxysterols like 
      that detectable in hypercholesterolemic individuals led to a marked 
      overexpression of TGFbeta1 and MCP-1. Both HNE and oxysterols then appear to be 
      candidates for a primary role in the progression of the atherosclerotic process.
FAU - Leonarduzzi, Gabriella
AU  - Leonarduzzi G
AD  - Department of Clinical and Biological Sciences, University of Turin, Turin, 
      Italy.
FAU - Chiarpotto, Elena
AU  - Chiarpotto E
FAU - Biasi, Fiorella
AU  - Biasi F
FAU - Poli, Giuseppe
AU  - Poli G
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Mol Nutr Food Res
JT  - Molecular nutrition & food research
JID - 101231818
RN  - 0 (Aldehydes)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Sterols)
RN  - 0 (Transcription Factors)
RN  - 0 (oxidized low density lipoprotein)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - K1CVM13F96 (4-hydroxy-2-nonenal)
SB  - IM
MH  - Aldehydes/analysis/chemistry/*metabolism/pharmacology
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Atherosclerosis/*metabolism
MH  - Cell Nucleus/metabolism
MH  - Cholesterol/*metabolism
MH  - Gene Expression/drug effects
MH  - Humans
MH  - Inflammation
MH  - Lipoproteins, LDL/chemistry
MH  - Macrophage Activation/drug effects
MH  - Molecular Structure
MH  - Myocytes, Smooth Muscle/drug effects/physiology
MH  - Oxidation-Reduction
MH  - Signal Transduction
MH  - Sterols/chemistry/pharmacology
MH  - Transcription Factors/physiology
RF  - 36
EDAT- 2005/11/05 09:00
MHDA- 2006/02/17 09:00
CRDT- 2005/11/05 09:00
PHST- 2005/11/05 09:00 [pubmed]
PHST- 2006/02/17 09:00 [medline]
PHST- 2005/11/05 09:00 [entrez]
AID - 10.1002/mnfr.200500090 [doi]
PST - ppublish
SO  - Mol Nutr Food Res. 2005 Nov;49(11):1044-9. doi: 10.1002/mnfr.200500090.