PMID- 16271767
OWN - NLM
STAT- MEDLINE
DCOM- 20060522
LR  - 20061115
IS  - 0161-5890 (Print)
IS  - 0161-5890 (Linking)
VI  - 43
IP  - 10
DP  - 2006 Apr
TI  - HLA genes in Madeira Island (Portugal) inferred from sequence-based typing: 
      footprints from different origins.
PG  - 1726-8
AB  - Human leukocyte antigen (HLA)-A, HLA-B, and HLA-DRB1 polymorphisms were examined 
      in Madeira Island populations. The data was obtained at high-resolution level, 
      using sequence-based typing (SBT). The most frequent alleles at each loci were: 
      A*020101 (24.6%), B*5101 (9.7%), B*440201 (9.2%), and DRB1*070101 (15.7%). The 
      predominant three-loci haplotypes in Madeira were A*020101-B*510101-DRB1*130101 
      (2.7%) and A*010101-B*0801-DRB1*030101 (2.4%), previously found in north and 
      central Portugal. The present study corroborates historical sources and other 
      genetic studies that say Madeira were populated not only by Europeans, mostly 
      Portuguese, but also sub-Saharan Africans due to slave trade. Comparison with 
      other populations shows that Madeira experienced a stronger African influence due 
      to slave trade than Portugal mainland and even the Azores archipelago. Despite 
      this African genetic input, haplotype and allele frequencies were predominantly 
      from European origin, mostly common to mainland Portugal.
FAU - Spinola, Helder
AU  - Spinola H
AD  - Human Genetics Laboratory, University of Madeira, Campus of Penteada, 9000-399 
      Funchal, Portugal.
FAU - Bruges-Armas, Jacome
AU  - Bruges-Armas J
FAU - Mora, Marian Gantes
AU  - Mora MG
FAU - Middleton, Derek
AU  - Middleton D
FAU - Brehm, Antonio
AU  - Brehm A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051104
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Gene Frequency
MH  - HLA Antigens/*genetics
MH  - Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - *Polymorphism, Genetic
MH  - Portugal
EDAT- 2005/11/08 09:00
MHDA- 2006/05/23 09:00
CRDT- 2005/11/08 09:00
PHST- 2005/08/26 00:00 [received]
PHST- 2005/10/01 00:00 [accepted]
PHST- 2005/11/08 09:00 [pubmed]
PHST- 2006/05/23 09:00 [medline]
PHST- 2005/11/08 09:00 [entrez]
AID - S0161-5890(05)00357-3 [pii]
AID - 10.1016/j.molimm.2005.10.001 [doi]
PST - ppublish
SO  - Mol Immunol. 2006 Apr;43(10):1726-8. doi: 10.1016/j.molimm.2005.10.001. Epub 2005 
      Nov 4.