PMID- 16271950
OWN - NLM
STAT- MEDLINE
DCOM- 20060123
LR  - 20071115
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 163
IP  - 1
DP  - 2005 Nov
TI  - Random aneuploidy and telomere capture in chronic lymphocytic leukemia and 
      chronic myeloid leukemia patients.
PG  - 12-6
AB  - Telomeric regions of the human genome are of particular interest, because 
      rearrangements of these regions are difficult to identify by conventional 
      chromosome banding technology. With the advent of molecular cytogenetic 
      techniques such as fluorescence in situ hybridization (FISH), it has been 
      possible to investigate the terminus in cytogenetically visible terminal 
      deletions and telomere rearrangements. We investigated telomere capture and 
      aneuploidy rates in chronic lymphocytic leukemia (CLL) and chronic myeloid 
      leukemia (CML) patients, as well as in healthy control subsets. Using a FISH 
      technique, we estimated the random aneuploidy and telomere capture of the 21q22, 
      SNRPN, and 15qter loci. Higher aneuploidy rates were found in the leukocytes of 
      CLL and CML patients, compared with the control group, for the 21q22 and SNRPN 
      loci. There was no difference in the aneuploidy rate between the CML and CLL 
      groups. Telomere capture was found in the two groups (CLL and CML), but not in 
      the control group. We propose that the telomere capture phenomenon is much more 
      common than has been reported in the literature; however, its prognostic 
      significance is yet to be established.
FAU - Amiel, A
AU  - Amiel A
AD  - Genetic Institute, Meir Medical Center, Kfar-Saba 44281, Israel. 
      amielaliza@clalit.org.il
FAU - Goldzak, G
AU  - Goldzak G
FAU - Gaber, E
AU  - Gaber E
FAU - Yosef, G
AU  - Yosef G
FAU - Fejgin, M D
AU  - Fejgin MD
FAU - Yukla, M
AU  - Yukla M
FAU - Lishner, M
AU  - Lishner M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aneuploidy
MH  - Bone Marrow Cells/pathology
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 15
MH  - *Chromosomes, Human, Pair 21
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics/pathology
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics/pathology
MH  - Middle Aged
MH  - Telomere/*genetics
MH  - Translocation, Genetic
MH  - *Trisomy
EDAT- 2005/11/08 09:00
MHDA- 2006/01/24 09:00
CRDT- 2005/11/08 09:00
PHST- 2005/03/02 00:00 [received]
PHST- 2005/04/12 00:00 [revised]
PHST- 2005/04/13 00:00 [accepted]
PHST- 2005/11/08 09:00 [pubmed]
PHST- 2006/01/24 09:00 [medline]
PHST- 2005/11/08 09:00 [entrez]
AID - S0165-4608(05)00214-1 [pii]
AID - 10.1016/j.cancergencyto.2005.04.007 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2005 Nov;163(1):12-6. doi: 
      10.1016/j.cancergencyto.2005.04.007.