PMID- 16271962
OWN - NLM
STAT- MEDLINE
DCOM- 20060123
LR  - 20060214
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 163
IP  - 1
DP  - 2005 Nov
TI  - Renal oncocytoma with loss of chromosomes Y and 1 evolving to papillary carcinoma 
      in connection with gain of chromosome 7. Coincidence or progression?
PG  - 81-5
AB  - Hybrid tumors of the kidney are not rare. Previous studies of hybrid renal tumors 
      have been valuable for the understanding of the pathogenesis and progression 
      pathways of renal cell neoplasm. In this paper we describe the morphologic, 
      immunohistochemical, and genetic features of 2 oncocytomas with evolving 
      papillary renal cell carcinoma (PRCC) in a nephrectomy specimen of a 60-year old 
      male. The patient was referred for urologic oncology consultation after the 
      incidental discovery of a renal tumor. Nephrectomy was performed and two separate 
      masses were present grossly. The tumors were stained with hematoxylin and eosin, 
      cytokeratin 7 and vimentin. Genetic studies included conventional metaphase 
      cytogenetics and fluorescence in situ hybridization (FISH). Morphologically, both 
      tumors were oncocytomas with numerous microscopic papillary nests and psammoma 
      bodies. Papillary carcinoma nests were highlighted with cytokeratin 7 and 
      vimentin positivity and were more prominent in the larger tumor. Conventional 
      cytogenetics and FISH demonstrated loss of chromosomes Y and 1 and gains of 
      chromosome 7. We postulate that the PRCC represents a neoplastic progression by 
      the gain of chromosome 7 oncocytoma with -Y and -1.
FAU - Al-Saleem, Tahseen
AU  - Al-Saleem T
AD  - Department of Pathology, Medical Science Division, Fox Chase Cancer Center, 
      Philadelphia, PA 19111, USA. T_alsaleem@fccc.edu
FAU - Balsara, Binaifer R
AU  - Balsara BR
FAU - Liu, Zemin
AU  - Liu Z
FAU - Feder, Madelyn
AU  - Feder M
FAU - Testa, Joseph R
AU  - Testa JR
FAU - Wu, Hong
AU  - Wu H
FAU - Greenberg, Richard E
AU  - Greenberg RE
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adenoma, Oxyphilic/*genetics/pathology
MH  - Carcinoma, Papillary/*genetics/pathology
MH  - *Chromosome Aberrations
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 7
MH  - *Chromosomes, Human, Y
MH  - Disease Progression
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Kidney Neoplasms/*genetics/pathology
MH  - Male
MH  - Metaphase
MH  - Middle Aged
EDAT- 2005/11/08 09:00
MHDA- 2006/01/24 09:00
CRDT- 2005/11/08 09:00
PHST- 2005/04/22 00:00 [received]
PHST- 2005/05/17 00:00 [revised]
PHST- 2005/05/24 00:00 [accepted]
PHST- 2005/11/08 09:00 [pubmed]
PHST- 2006/01/24 09:00 [medline]
PHST- 2005/11/08 09:00 [entrez]
AID - S0165-4608(05)00297-9 [pii]
AID - 10.1016/j.cancergencyto.2005.05.011 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2005 Nov;163(1):81-5. doi: 
      10.1016/j.cancergencyto.2005.05.011.